Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 22:36:102441.
doi: 10.1016/j.pmedr.2023.102441. eCollection 2023 Dec.

Relationship between body fat ratio and inflammatory markers in a Chinese population of adult male smokers

Xiu Zang  1   2 , Xiangyu Meng  3 , Xuekui Liu  1   2 , Houfa Geng  1   2 , Jun Liang  1   2   4
Affiliations
Review

Relationship between body fat ratio and inflammatory markers in a Chinese population of adult male smokers

Xiu Zang et al. Prev Med Rep. .

Abstract

Objective: To explore the correlation between changes in the body fat ratio (BFR) and peripheral blood inflammatory markers according to smoking status in the adult Chinese male population.

Methods: A total of 865 participants (aged 20-70 years) were included. All participants underwent a physical health examination at Xiguzhou Central Hospital between October 2015 and July 2016, including measurements of body mass index (BMI), BFR, white blood cell [WBC] count, and neutrophil-lymphocyte ratio [NLR].

Results: WBCs count and NLR were significantly higher in adult male smokers than in non-smokers (P = 0.00). According to the BFR stratification analysis, WBC count and NLR significantly increased in accordance with BFR (P = 0.00). This finding remained significant after adjusting for relevant confounding factors (P < 0.05). Two-factor stratified analysis of smoking status and BFR showed that WBC count and NLR in the smoking population were higher than in nonsmokers, regardless of BFR. The interaction model showed that BFR and smoking status affected WBC count and NLR changes (P < 0.05). A significant positive correlation was found between WBC count, NLR, and BFR in adult male smokers; however, there was no significant correlation with BMI. There was an interaction between smoking and BFR, both of which synergistically affected changes in inflammatory markers, including WBC count and NLR.

Conclusion: WBC count and NLR of smokers with a high BFR were significantly higher than those of nonsmokers with a low BFR. It is important to provide evidence-based medical evidence for social tobacco control and to reduce BFR.

Keywords: Adult male; Body fat ratio; Inflammatory markers; Neutrophil lymphocyte ratio; Smoking; White blood cell count.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Changes in BFR in smokers and non-smokers interact with WBC Note:BFR: body fat ratio; WBC: white blood cell.
Fig. 2
Fig. 2
Changes in BFR in smokers and non-smokers interact with NLR Note:BFR: body fat ratio; NLR: the neutrophil–lymphocyte ratio.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Aguilar-Valles A., Inoue W., Rummel C., Luheshi G.N. Obesity, adipokines and neuroinflammation. Neuropharmacology. 2015;96:124–134. - PubMed
    1. Aoshiba K., Tamaoki J., Nagai A. Acute cigarette smoke exposure induces apoptosis of alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001;281:L1392–L1401. doi: 10.1152/ajplung.2001.281.6.L1392. - DOI - PubMed
    1. Canoy D., Wareham N., Luben R., Welch A., Bingham S., Day N., Khaw K.T. Cigarette smoking and fat distribution in 21,828 British men and women: a population-based study. Obes. Res. 2005;13:1466–1475. doi: 10.1038/oby.2005.177. - DOI - PubMed
    1. Czernichow S., Kengne A.P., Stamatakis E., Hamer M., Batty G.D. Body mass index, waist circumference and waist-hip ratio: which is the better discriminator of cardiovascular disease mortality risk?: Evidence from an individual-participant meta-analysis of 82 864 participants from nine cohort studies. Obes. Rev. 2011;12:680–687. doi: 10.1111/j.1467-789X.2011.00879.x. - DOI - PMC - PubMed
    1. Fairchild T.J., Klakk H., Heidemann M., Grøntved A., Wedderkopp N. Insulin sensitivity is reduced in children with high body-fat regardless of BMI. Int. J. Obes. (Lond) 2018;42:985–994. doi: 10.1038/s41366-018-0043-z. - DOI - PubMed

LinkOut - more resources