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Review
. 2023 Sep 22:36:102441.
doi: 10.1016/j.pmedr.2023.102441. eCollection 2023 Dec.

Relationship between body fat ratio and inflammatory markers in a Chinese population of adult male smokers

Xiu Zang  1   2 , Xiangyu Meng  3 , Xuekui Liu  1   2 , Houfa Geng  1   2 , Jun Liang  1   2   4
Affiliations
Review

Relationship between body fat ratio and inflammatory markers in a Chinese population of adult male smokers

Xiu Zang et al. Prev Med Rep. .

Abstract

Objective: To explore the correlation between changes in the body fat ratio (BFR) and peripheral blood inflammatory markers according to smoking status in the adult Chinese male population.

Methods: A total of 865 participants (aged 20-70 years) were included. All participants underwent a physical health examination at Xiguzhou Central Hospital between October 2015 and July 2016, including measurements of body mass index (BMI), BFR, white blood cell [WBC] count, and neutrophil-lymphocyte ratio [NLR].

Results: WBCs count and NLR were significantly higher in adult male smokers than in non-smokers (P = 0.00). According to the BFR stratification analysis, WBC count and NLR significantly increased in accordance with BFR (P = 0.00). This finding remained significant after adjusting for relevant confounding factors (P < 0.05). Two-factor stratified analysis of smoking status and BFR showed that WBC count and NLR in the smoking population were higher than in nonsmokers, regardless of BFR. The interaction model showed that BFR and smoking status affected WBC count and NLR changes (P < 0.05). A significant positive correlation was found between WBC count, NLR, and BFR in adult male smokers; however, there was no significant correlation with BMI. There was an interaction between smoking and BFR, both of which synergistically affected changes in inflammatory markers, including WBC count and NLR.

Conclusion: WBC count and NLR of smokers with a high BFR were significantly higher than those of nonsmokers with a low BFR. It is important to provide evidence-based medical evidence for social tobacco control and to reduce BFR.

Keywords: Adult male; Body fat ratio; Inflammatory markers; Neutrophil lymphocyte ratio; Smoking; White blood cell count.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Changes in BFR in smokers and non-smokers interact with WBC Note:BFR: body fat ratio; WBC: white blood cell.
Fig. 2
Fig. 2
Changes in BFR in smokers and non-smokers interact with NLR Note:BFR: body fat ratio; NLR: the neutrophil–lymphocyte ratio.
See this image and copyright information in PMC

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