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Case Reports
. 2023 Jul 20;2(4):100148.
doi: 10.1016/j.jacig.2023.100148. eCollection 2023 Nov.

A fatal eosinophilic granulomatosis with polyangiitis case presenting intracerebral hemorrhage and thrombocytopenia

Quan Hong Nguyen  1 , Hang Thi-Thuy Tran  1 , Tuyen Manh Nguyen  2 , Ngoc Hoang Nguyen  3
Affiliations
Case Reports

A fatal eosinophilic granulomatosis with polyangiitis case presenting intracerebral hemorrhage and thrombocytopenia

Quan Hong Nguyen et al. J Allergy Clin Immunol Glob. .

Abstract

We report the case of a patient with eosinophilic granulomatosis with polyangiitis and unexplained thrombocytopenia that culminated in a fatal intracerebral hemorrhage. Because vessel damage associated with thrombocytopenia could be the leading cause of fatal hemorrhage, more urgent treatment of thrombocytopenia should be performed in such cases.

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Figures

Fig 1
Fig 1
Biopsy specimen of purpura fulminans on the lower limb showed the eosinophilic infiltrates (A) and fibrinoid necrosis of vessel wall with eosinophilic infiltrates in the dermis and subcutaneous fat magnification (B). Hematoxylin and eosin staining; original magnification, ×20.
Fig 2
Fig 2
Brain computed tomography scan (A-H) showed massive intracerebral hemorrhage in the left temporal lobe and blood in the subarachnoid space and ventricles at day 9 and brain angiogram (I) showed no abnormalities at day 1.
See this image and copyright information in PMC

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