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Review
. 2023 Sep 21:20:100257.
doi: 10.1016/j.metop.2023.100257. eCollection 2023 Dec.

Prevention of Alzheimer's disease through diet: An exploratory review

Nusrat Zahan Bhuiyan  1 , Md Kamrul Hasan  1   2 , Zimam Mahmud  3 , Md Sabbir Hossain  1 , Atiqur Rahman  3
Affiliations
Review

Prevention of Alzheimer's disease through diet: An exploratory review

Nusrat Zahan Bhuiyan et al. Metabol Open. .

Abstract

Introduction: This exploratory review article describes about the genetic factors behind Alzheimer's disease (AD), their association with foods, and their relationships with cognitive impairment. It explores the dietary patterns and economic challenges in AD prevention.

Methods: Scopus, PubMed and Google Scholar were searched for articles that examined the relationships between Diets, Alzheimer's Disease (AD), and Socioeconomic conditions in preventative Alzheimer's disease studies. Graphs and Network analysis data were taken from Scopus under the MeSH search method, including words, Alzheimer's, APoE4, Tau protein, APP, Amyloid precursor protein, Beta-Amyloid, Aβ, Mediterranean Diet, MD, DASH diet, MIND diet, SES, Socioeconomic, Developed country, Underdeveloped country, Preventions. The network analysis was done through VOS viewer.

Results: Mediterranean diet (MD) accurately lowers AD (Alzheimer's Disease) risk to 53% and 35% for people who follow it moderately. MIND scores had a statistically significant reduction in AD rate compared to those in the lowest tertial (53% and 35% reduction, respectively). Subjects with the highest adherence to the MD and DASH had a 54% and 39% lower risk of developing AD, respectively, compared to those in the lowest tertial. Omega-6, PUFA, found in nuts and fish, can play most roles in the clearance of Aβ. Vitamin D inhibits induced fibrillar Aβ apoptosis. However, the high cost of these diet components rise doubt about the effectiveness of AD prevention through healthy diets.

Conclusion: The finding of this study revealed an association between diet and the effects of the chemical components of foods on AD biomarkers. More research is required to see if nutrition is a risk or a protective factor for Alzheimer's disease to encourage research to be translated into therapeutic practice and to clarify nutritional advice.

Keywords: AD biomarkers; Alzheimer's disease; DASH diet; Diets; MIND diet; Mediterranean diet.

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Conflict of interest statement

All authors declare no conflicts of interest, financial or otherwise.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Relationship among primary and secondary prevention factors of AD.
Fig. 2
Fig. 2
Network analysis to see the most focused point in AD research from previous research till 2022.
Fig. 3
Fig. 3
Network analysis to see the most focused factors in AD prevention from 2015 to 2022.
Fig. 4
Fig. 4
Published papers in the Scopus database on APoE4, Tau protein, APP, and Beta-amyloid focusing AD cure.
Fig. 5
Fig. 5
Published papers in the Scopus database on preventive facts about the three diets.
See this image and copyright information in PMC

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