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Comment
. 2023 Dec 15;29(24):4993-4995.
doi: 10.1158/1078-0432.CCR-23-1909.

Can We De-escalate Therapy for HER2-Positive Metastatic Breast Cancer?

Laura A Huppert  1 , Hope S Rugo  2
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Comment

Can We De-escalate Therapy for HER2-Positive Metastatic Breast Cancer?

Laura A Huppert et al. Clin Cancer Res. .

Abstract

A recent phase Ib/II trial evaluated the combination of tucatinib, letrozole, and palbociclib in patients with HR+/HER2+ metastatic breast cancer, demonstrating a manageable safety profile and encouraging efficacy data. An all-oral, chemotherapy-free regimen is an appealing strategy, and could be a possible maintenance or primary therapy option in select patients. See related article by Shagisultanova et al., p. 5021.

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