Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct 2;13(1):16535.
doi: 10.1038/s41598-023-43434-x.

Factors associated with poorer quality of life in people living with HIV in southwestern France in 2018-2020 (ANRS CO3 AQUIVIH-NA cohort: QuAliV study)

Diana Barger  1 , Mojgan Hessamfar  2   3   4 , Didier Neau  5 , Sophie Farbos  6 , Olivier Leleux  7 , Charles Cazanave  5 , Nicolas Rouanes  8 , Pierre Duffau  3   9 , Estibaliz Lazaro  10 , Patrick Rispal  11 , François Dabis  2   4 , Linda Wittkop  2   7   12   13 , Fabrice Bonnet  2   3   7
Affiliations

Factors associated with poorer quality of life in people living with HIV in southwestern France in 2018-2020 (ANRS CO3 AQUIVIH-NA cohort: QuAliV study)

Diana Barger et al. Sci Rep. .

Abstract

We evaluated people living with Human Immunodeficiency Virus' (PLWH) quality of life (QoL) and assessed whether their demographic, disease-related, socioeconomic, or behavioral characteristics were associated with poorer QoL. ANRS CO3 AQUIVIH-NA cohort participants (Nouvelle Aquitaine, France) were recruited to a cross-sectional study (2018-2020) and their QoL assessed (WHOQOL-BREF). We calculated median (Q1, Q3) QoL domain scores and assessed factors associated with poorer median QoL using bivariable and multivariable quartile regression. Of the 965 PLWH included, 98.4% were on antiretroviral therapy, 94.7% were virally-suppressed, 63.5% reported good/very good QoL. Median scores (0-100) were highest for physical (69;Q1, Q3: 56, 81) and environmental (69; 56, 75) QoL and lowest for social (56; 44, 69) and psychological (56; 44, 69) QoL. PLWH with ≥ 3 comorbidities, HIV-related stigma, or income of < 1500€/month had poorer median adjusted physical, psychological, social, and environmental QoL scores compared to reference groups. While more than half of PLWH reported good/very good QoL, we have not achieved good QoL in 90% of PLWH. Multi-morbidity, HIV-related stigma, and social determinants were consistently and independently associated with poorer QoL. Addressing structural factors in addition to those indirectly related to HIV is required to attain good QoL in all PLWH.

PubMed Disclaimer

Conflict of interest statement

MH, DN, SF, OL, NR, PD, CC, EL, PR, FD, and LW have no relevant financial or nonfinancial competing interests to disclose. DB received speaking fees from Gilead Sciences and ViiV Healthcare and was compensated as an expert on a Gilead Sciences advisory board outside the submitted work. FB reports non-financial support from Gilead Sciences, Janssen, ViiV Healthcare, and MSD, and personal fees from Gilead Sciences, Janssen, ViiV Healthcare, and MSD outside the submitted work.

Figures

Figure 1
Figure 1
Coefficient plot: Bivariable and multivariable quartile regression analysis of physical QoL.
Figure 2
Figure 2
Coefficient plot: Bivariable and multivariable quartile regression analysis of psychological QoL.
Figure 3
Figure 3
Coefficient plot: Bivariable and multivariable quartile regression analysis of social QoL.
Figure 4
Figure 4
Coefficient plot: Bivariable and multivariable quartile regression analysis of environmental QoL.
See this image and copyright information in PMC

References

    1. Hoen B, Bonnet F, Delaugerre C, et al. French 2013 guidelines for antiretroviral therapy of HIV-1 infection in adults. J. Int. AIDS Soc. 2014;17:19034. doi: 10.7448/IAS.17.1.19034. - DOI - PMC - PubMed
    1. UNAIDS. 90–90–90—An ambitious treatment target to help end the AIDS epidemic (2014).
    1. Lazarus JV, Safreed-Harmon K, Barton SE, et al. Beyond viral suppression of HIV—The new quality of life frontier. BMC Med. 2016;14(1):94. doi: 10.1186/s12916-016-0640-4. - DOI - PMC - PubMed
    1. Lazarus, J. V., Safreed-Harmon, K. Depicting a New Target For the HIV Response: How Do You See the ‘Fourth 90’? Barcelona; 2018. Available from: https://www.isglobal.org/en/healthisglobal/-/custom-blog-portlet/visuall... [Last Accessed; 4 February 2021].
    1. The World Health Organization Quality of Life assessment (WHOQOL). position paper from the World Health Organization. Soc. Sci. Med. 1982;41(10):1403–1409. doi: 10.1016/0277-9536(95)00112-k. - DOI - PubMed

Publication types