Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov;46(11):1504-1516.
doi: 10.1007/s00270-023-03567-y. Epub 2023 Oct 2.

Clinical Applications of PRP: Musculoskeletal Applications, Current Practices and Update

Ahmad M Aljefri  1 , Cormac O Brien  2 , Tien Jin Tan  3 , Adnan M Sheikh  2 , Hugue Ouellette  2 , Salem Bauones  4
Affiliations
Review

Clinical Applications of PRP: Musculoskeletal Applications, Current Practices and Update

Ahmad M Aljefri et al. Cardiovasc Intervent Radiol. 2023 Nov.

Abstract

Musculoskeletal tissues are often subjected to deleterious effects stemming from traumatic injuries or degenerative pathologies, which can impede the body's natural repair response. The advent of regenerative medicine has emerged as a promising therapeutic approach in modern patient care. Among the interventions in this cutting-edge field, platelet-rich plasma (PRP) and cell-based therapies, such as mesenchymal stem cells, have garnered significant attention. In this article, we endeavor to provide an overview of the current practices and recent developments in PRP therapy, with a particular emphasis on the clinical applications for musculoskeletal pathologies.

Keywords: Osteoarthritis; PRP; Platelet-rich plasma; Regenerative medicine; Tendinopathy.

PubMed Disclaimer

References

    1. Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020;21(20):7794. https://doi.org/10.3390/ijms21207794 . - DOI - PubMed - PMC
    1. Mathew J, Sankar P, Varacallo M. Physiology, Blood plasma. 2022 Apr 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022; PMID: 30285399.
    1. Gremmel T, Frelinger AL 3rd, Michelson AD. Platelet physiology. Semin Thromb Hemost. 2016;42(3):191–204. https://doi.org/10.1055/s-0035-1564835 . (Epub 2016 Feb 29 PMID: 26926581). - DOI - PubMed
    1. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 2001;10:225–8. - PubMed - DOI
    1. Rand E, Gellhorn AC. The healing cascade: facilitating and optimizing the system. Phys Med Rehabil Clin N Am. 2016;27(4):765–81. - PubMed - DOI

LinkOut - more resources