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Comment
. 2023 Dec;19(12):754-755.
doi: 10.1038/s41581-023-00776-z.

MSC therapy for diabetic kidney disease and nephrotic syndrome

Bo Lu  1   2 , Lilach O Lerman  3
Affiliations
Comment

MSC therapy for diabetic kidney disease and nephrotic syndrome

Bo Lu et al. Nat Rev Nephrol. 2023 Dec.
No abstract available

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Conflict of interest statement

Competing interests

L.O.L. is an advisor to CureSpec and Ribocure Pharmaceuticals. B.L. declares no competing interests.

Figures

Figure 1.
Figure 1.. Factors affecting functions of MSCs
Created with BioRender.com Abbreviations: MSCs, mesenchymal stem cells; BM-MSCs, bone marrow-derived mesenchymal stem cells; AD-MSCs, adipose tissue-derived mesenchymal stem cells; HCB-MSCs, human umbilical cord blood mesenchymal stem cells; UC-MSCs, umbilical cord mesenchymal stem cells.
See this image and copyright information in PMC

Comment on

References

    1. Rožanc J. et al. Mesenchymal stem cells isolated from paediatric paravertebral adipose tissue show strong osteogenic potential. Biomedicines 10, 378 (2022). - PMC - PubMed
    1. Perico N. et al. Safety and preliminary efficacy of mesenchymal stromal cell (ORBCEL-M Cell) therapy in diabetic kidney disease: a randomized clinical trial (NEPHSTROM). J. Am. Soc. Nephrol 10.1681/ASN.0000000000000189 (2023). - DOI - PMC - PubMed
    1. Vivarelli M. et al. A phase 1 study of autologous mesenchymal stromal cells for severe steroid-dependent nephrotic syndrome. JCI Insight 10.1172/jci.insight.169424 (2023). - DOI - PMC - PubMed
    1. Packham DK, Fraser IR, Kerr PG & Segal KR Allogeneic mesenchymal precursor cells (MPC) in diabetic nephropathy: a randomized, placebo-controlled, dose escalation study. EBioMedicine 12, 263–269 (2016). - PMC - PubMed
    1. Morello W. et al. First clinical application of cord blood mesenchymal stromal cells in children with multi-drug resistant nephrotic syndrome. Stem Cell Res. Ther 13, 420 (2022). - PMC - PubMed

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