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Case Reports
. 2023 Sep 30;11(10):e7718.
doi: 10.1002/ccr3.7718. eCollection 2023 Oct.

Angioinvasive Trichophyton rubrum associated necrotizing fasciitis in an immunocompromised patient

Michael J Davis  1 , Katelyn J Rypka  2 , Alexandra K Perron  3 , John Keilty  3 , Benjamin Wils  3 , Joshua Levine  3 , Anthony T Rezcallah  4 , Robin Solomon  5 , Noah Goldfarb  2 , Anjum Kaka  6
Affiliations
Case Reports

Angioinvasive Trichophyton rubrum associated necrotizing fasciitis in an immunocompromised patient

Michael J Davis et al. Clin Case Rep. .

Abstract

Angioinvasive dermatophytosis with necrotizing fasciitis can be a rare complication in immunocompromised patients with early surgical debridement, 12 weeks of oral terbinafine, and reduction in immunosuppression being a viable management strategy.

Keywords: Trichophyton rubrum; angioinvasive dermatophytosis; hematologic malignancy; immunosuppression; necrotizing fasciitis; terbinafine.

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Conflict of interest statement

Dr. Goldfarb has participated in clinical trials with Abbvie, Pfizer, Chemocentrix and DeepX Health, and has served on advisory boards and consulted for Novartis and Boehringer Ingelheim. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of any other companies or organizations.

Figures

FIGURE 1
FIGURE 1
Well‐demarcated annular plaque of the medial right lower extremity with dusky hemorrhagic crusts.
FIGURE 2
FIGURE 2
(A) Fungal elements demonstrated within a blood vessel from debrided right lower extremity tissue (Grocott's methenamine silver stain, magnification 20x). (B) Septated fungal elements demonstrated within subcutaneous tissue (Grocott's methenamine silver stain, magnification 40x). (C) Tissue demonstrating branching, septated fungal elements (Grocott's methenamine silver stain, magnification 60x). (D) Subcutaneous tissue demonstrating purulent inflammation (Hematoxylin and Eosin stain, magnification 40x).
FIGURE 3
FIGURE 3
Right lower extremity wound postoperative day 6 after four compartment fasciotomy and debridement.
See this image and copyright information in PMC

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