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. 2023 Apr-Jun;49(2):163-171.
doi: 10.12865/CHSJ.49.02.163. Epub 2023 Jun 30.

Clinical Evaluation of Periodontal Status and IL-6 Gingival Fluid Level in Patients with Sjogren's Syndrome

Dorin Nicolae Gheorghe  1   2 , Dora Maria Popescu  2 , Stefan Cristian Dinescu  3 , Mihail Virgil Boldeanu  1 , Petra Surlin  2 , Florentin Vreju  3 , Paulina Lucia Ciurea  3
Affiliations

Clinical Evaluation of Periodontal Status and IL-6 Gingival Fluid Level in Patients with Sjogren's Syndrome

Dorin Nicolae Gheorghe et al. Curr Health Sci J. 2023 Apr-Jun.

Abstract

The objective of the cross-sectional study was to assess periodontal and implant health condition among individuals diagnosed with Sjogren's Syndrome (SS), taking into account the clinical circumstances associated with this patient population. The clinical parameters employed to evaluate the periodontal status of both natural teeth and implants included: periodontal probing depth (PPD) measured at six sites per tooth/implant, clinical attachment level (CAL), bleeding on probing index (BOP), plaque index (PLQ). Gingival crevicular fluid samples were collected for interleukin-16 level evaluation. After clinical and immunological assessment of the study and control groups, the data was centralized, compiled and submitted for statistical analysis. In all four types of assessed periodontal parameters, there were statistically significant differences between the SS patients with no dental implants and the other test (SSi) and control groups (Cni and Ci). Nevertheless, in SS patients with dental implants, plaque levels were similar to that of controls. In addition, other periodontal parameters (PPD, BOP and CAL) were similar in SS patients with dental implants and controls, with no statistically significant difference. The highest GCF IL-6 levels were found in SS patients with no dental implants, the differences to the other study and control groups being statistically significant. In patients with SS and dental implants, there were no statistically significant differences to the other groups. Individuals diagnosed with Sjogren's Syndrome (SS) exhibit a less favorable periodontal condition compared to controls without SS. Notably, SS patients who undergo dental implant procedures demonstrate an improvement in their periodontal status. This highlights the importance of proactive and ongoing dental and periodontal surveillance for SS patients, aiming to decrease the risk of developing periodontal diseases.

Keywords: Periodontitis; Sjogren’s syndrome; dental implants; interleukin-6; periodontal status.

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Conflict of interest statement

None to declare

Figures

Figure 1
Figure 1
Demographic results: age, number of teeth and dental implants in study and control groups.
Figure 2
Figure 2
Clinical parameters results: PPD, BOP, PLQ and CAL levels in study groups (SSni, SSi) and control groups (Cni, Ci), *, **-statistically significant difference.
Figure 3
Figure 3
GCF IL-6 levels in study groups (SSni, SSi) and control groups (Cni, Ci) *, ** -statistically significant difference.
Figure 4
Figure 4
Correlation matrix for GCF IL-6 levels and clinical parameters in patients with no dental implants A: SSni group, B: Cni group.
Figure 5
Figure 5
Correlation matrix for GCF IL-6 levels and clinical parameters in patients with dental implants A: SSi group, B: Ci group
See this image and copyright information in PMC

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