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. 2023 Dec 12;11(6):e0292223.
doi: 10.1128/spectrum.02922-23. Epub 2023 Oct 3.

Carbapenem resistance in extensively drug-resistant Salmonella enterica serovar Agona and AmpC β-lactamase-producing S. Infantis

Ping-Chun Hsu  1 , You-Wun Wang  2 , Bo-Han Chen  2 , Yu-Ping Hong  2 , Ru-Hsiou Teng  2 , Po-Yu Liu  1 , Chien-Shun Chiou  2
Affiliations

Carbapenem resistance in extensively drug-resistant Salmonella enterica serovar Agona and AmpC β-lactamase-producing S. Infantis

Ping-Chun Hsu et al. Microbiol Spectr. .

Abstract

Carbapenem resistance arising from the loss of porins is commonly observed in extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase-producing strains of certain Enterobacteriaceae genera, including Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. However, this resistance mechanism is rarely reported in the Salmonella genus. To address this knowledge gap, our study offers genetic evidence demonstrating that the loss of two specific porins (OmpC_378 and OmpD) is crucial for the development of carbapenem resistance in Salmonella ESBL and AmpC β-lactamase-producing strains. Furthermore, our findings reveal that most Salmonella serovars carry seven porin parathologs, with OmpC_378 and OmpD being the key porins involved in the development of carbapenem resistance in Salmonella strains.

Keywords: Salmonellosis; antimicrobial resistance; carbapenem resistance; extensively drug-resistant (XDR); non-typhoidal salmonella (NTS); transposon; whole-genome sequencing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig 1
Fig 1
(A) Schematic map of IS640 composite transposon in plasmid pR18.0877_278k (GenBank accession no. CP037959.1) and IS15DI composite transposon in the chromosome of S. Agona R21.2429 (accession no. CP090929.1); (B) ISEcp1- bla CMY-2-harboring segments in the chromosome and plasmid pR13.1986_94k of S. Infantis strain R13.1986 (accession no. CP129384.1 and CP129386.1).
Fig 2
Fig 2
Differences in amino acid sequences of porins found in S. Agona R21.0464 (accession no. CP093402.1), S. Infantis R21.0914 (CP121066.1), and S. Typhimurium R18.0292 (CP100739.1).
See this image and copyright information in PMC

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Supplementary concepts