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. 2024 Jan 1;38(1):85-94.
doi: 10.1097/QAD.0000000000003740. Epub 2023 Sep 29.

Lower endoscopy, early-onset, and average-onset colon cancer among Medicaid beneficiaries with and without HIV

Corinne E Joshu  1   2   3 , Keri L Calkins  1   4 , Jacqueline E Rudolph  1 , Xiaoqiang Xu  5 , Eryka Wentz  1 , Sally B Coburn  1 , Maneet Kaur  1 , Filip Pirsl  1 , Richard D Moore  1   5 , Bryan Lau  1   2   3   5
Affiliations

Lower endoscopy, early-onset, and average-onset colon cancer among Medicaid beneficiaries with and without HIV

Corinne E Joshu et al. AIDS. .

Abstract

Background: Studies suggest a lower colorectal cancer (CRC) risk and lower or similar CRC screening among people with HIV (PWH) compared with the general population. We evaluated the incidence of lower endoscopy and average-onset (diagnosed at ≥50) and early-onset (diagnosed at <50) colon cancer by HIV status among Medicaid beneficiares with comparable sociodemographic factors and access to care.

Methods: We obtained Medicaid Analytic eXtract (MAX) data from 2001 to 2015 for 14 states. We included 41 727 243 and 42 062 552 unique individuals with at least 7 months of continuous eligibility for the endoscopy and colon cancer analysis, respectively. HIV and colon cancer diagnoses and endoscopy procedures were identified from inpatient and other nondrug claims. We used Cox proportional hazards regression models to assess endoscopy and colon cancer incidence, controlling for age, sex, race/ethnicity, calendar year and state of enrollment, and comorbidities conditions.

Results: Endoscopy and colon cancer incidence increased with age in both groups. Compared with beneficiaries without HIV, PWH had an increased hazard of endoscopy; this association was strongest among those 18-39 years [hazard ratio: 1.85, 95% confidence interval (95% CI) 1.77-1.92] and attenuated with age. PWH 18-39 years also had increased hazard of early-onset colon cancer (hazard ratio: 1.66, 95% CI:1.05-2.62); this association was attenuated after comorbidity adjustment. Hazard ratios were null among all beneficiaries less than 50 years of age. PWH had a lower hazard of average-onset colon cancer compared with those without HIV (hazard ratio: 0.79, 95% CI: 0.66-0.94).

Conclusion: PWH had a higher hazard of endoscopy, particularly at younger ages. PWH had a lower hazard of average-onset colon cancer. Early-onset colon cancer was higher among the youngest PWH but not associated with HIV overall.

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Conflict of interest statement

Disclosures: The authors disclose no potential conflicts of interest.

Figures

Figure 1.
Figure 1.
Cumulative probability of being free of an endoscopy by age and HIV status among Medicaid beneficiaries from 14 states, 2001-2015. Beneficiaries with HIV in dashed line; beneficiaries without HIV in solid line. Endoscopy at <50 years shown for males in panel A and for females in panel B. Endoscopy at ≥50 years shown for males in panel C and for females in panel D.
Figure 1.
Figure 1.
Cumulative probability of being free of an endoscopy by age and HIV status among Medicaid beneficiaries from 14 states, 2001-2015. Beneficiaries with HIV in dashed line; beneficiaries without HIV in solid line. Endoscopy at <50 years shown for males in panel A and for females in panel B. Endoscopy at ≥50 years shown for males in panel C and for females in panel D.
Figure 2.
Figure 2.
Cumulative probability of being free of colon cancer by age and HIV status among Medicaid beneficiaries from 14 states, 2001-2015. Beneficiaries with HIV in dashed line; beneficiaries without HIV in solid line. Colon cancer at <50 years shown for males in panel A and for females in panel B. Colon cancer at ≥50 years shown for males in panel C and for females in panel D.
Figure 2.
Figure 2.
Cumulative probability of being free of colon cancer by age and HIV status among Medicaid beneficiaries from 14 states, 2001-2015. Beneficiaries with HIV in dashed line; beneficiaries without HIV in solid line. Colon cancer at <50 years shown for males in panel A and for females in panel B. Colon cancer at ≥50 years shown for males in panel C and for females in panel D.
See this image and copyright information in PMC

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