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Editorial
. 2024 Jan;70(1):8-10.
doi: 10.1165/rcmb.2023-0327ED.

Pleural Fibrosis: Now That's What mTORC(ing) About

Steven E Mutsaers  1 , Vera P Krymskaya  2
Affiliations
Editorial

Pleural Fibrosis: Now That's What mTORC(ing) About

Steven E Mutsaers et al. Am J Respir Cell Mol Biol. 2024 Jan.
No abstract available

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Figures

Figure 1.
Figure 1.
The contribution of mTORC2 (mTOR complex 1) and downstream molecules SGK1 and NDRG1 to TGF (transforming growth factor) β–induced mesothelial-to-mesenchymal transition. Figure adapted by permission from Lamouille and colleagues in Ref. and created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

    1. Mutsaers SE, Birnie K, Lansley S, Herrick SE, Lim CB, Prêle CM. Mesothelial cells in tissue repair and fibrosis. Front Pharmacol . 2015;6:113. - PMC - PubMed
    1. Mutsaers SE, Prele CM, Brody AR, Idell S. Pathogenesis of pleural fibrosis. Respirology . 2004;9:428–440. - PubMed
    1. Hinz B. Myofibroblasts. Exp Eye Res . 2016;142:56–70. - PubMed
    1. Tucker TA, Idell S. Update on novel targeted therapy for pleural organization and fibrosis. Int J Mol Sci . 2022;23:1587. - PMC - PubMed
    1. Budi EH, Schaub JR, Decaris M, Turner S, Derynck R. TGF-β as a driver of fibrosis: physiological roles and therapeutic opportunities. J Pathol . 2021;254:358–373. - PubMed

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