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Review
. 2023 Sep 1;15(9):e44543.
doi: 10.7759/cureus.44543. eCollection 2023 Sep.

Public Health Approach in the Elimination and Control of Cervical Cancer: A Review

Affiliations
Review

Public Health Approach in the Elimination and Control of Cervical Cancer: A Review

John Kessellie Jallah et al. Cureus. .

Abstract

Public health experts worldwide have emphasized cervical cancer since it is a substantial global health burden primarily affecting women. This article thoroughly reviews the public health approach to eradicating and managing cervical cancer. The public health community seeks to lower the prevalence, morbidity, and mortality linked to this preventable disease by integrating primary prevention by means of vaccination against the human papillomavirus (HPV), secondary prevention using screening and early identification, and tertiary prevention through improved therapy and supportive care. In order to accomplish broad vaccination coverage and ultimately effectively prevent cervical cancer, it remains crucial to address obstacles to vaccine accessibility, reluctance, and fair distribution. Early identification and subsequent treatments depend greatly on cervical cancer screening programs. This study explores several screening methods, such as Papanicolaou (Pap) tests based on cytology and cutting-edge technologies like molecular assays and HPV detection. The detection of precancerous lesions and early-stage malignancies, permitting prompt treatment, has shown significant promise when integrating these technologies into coordinated population-based screening programs. The study also underlines the significance of addressing cervical cancer burden inequities, particularly in resource-constrained areas where access to preventative and curative care is constrained. Innovative and affordable methods for addressing marginalized groups are studied, including community-based outreach programs, mobile health technology, and local healthcare practitioners and community leaders in awareness campaigns. The research also examines improvements in cervical cancer treatment procedures, such as surgery, radiation, chemotherapy, and immunotherapy. It improves therapeutic efficacy and patient survival rates by incorporating various modalities into a multidisciplinary strategy. Highlighted palliative care and psychological support are crucial for patients who have advanced cervical carcinoma.

Keywords: cervical cancer screening and therapy; cervical carcinoma; health disparities; human immunodeficiency virus (h.i.v.); human papillomavirus-immunization.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRISMA flow diagram for search strategy and selection criteria
Preferred Reporting Items for Systematic Reviews and Meta-Analyses

References

    1. World Health Organization call for action to eliminate cervical cancer globally. Gultekin M, Ramirez PT, Broutet N, Hutubessy R. Int J Gynecol Cancer. 2020;30:426–427. - PubMed
    1. ECHO Elimination of cervical cancer in Latin America (ECHO ELA): lessons learned from promoting WHO’s cervical cancer elimination goals ‘90-70-90'. Varon ML, Salcedo MP, Schmeler K, et al. JCO Glob Oncol. 2022;8:6.
    1. Cervical cancer screening programmes and age-specific coverage estimates for 202 countries and territories worldwide: a review and synthetic analysis. Bruni L, Serrano B, Roura E, et al. Lancet Glob Health. 2022;10:0–27. - PMC - PubMed
    1. Upregulation of translationally controlled tumor protein Is associated with cervical cancer progression. Zhu X, Ren J, Xu D, et al. Front Mol Biosci. 2021;8:686718. - PMC - PubMed
    1. Inhibition of cytosolic phospholipase A2 alpha increases chemosensitivity in cervical carcinoma through suppressing β-catenin signaling. Xu H, Sun Y, Zeng L, et al. Cancer Biol Ther. 2019;20:912–921. - PMC - PubMed

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