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Case Reports
. 2023 Sep 29;15(9):e46230.
doi: 10.7759/cureus.46230. eCollection 2023 Sep.

Melanoma With Cardiac Metastasis

Affiliations
Case Reports

Melanoma With Cardiac Metastasis

Sruthi L Kotaru et al. Cureus. .

Abstract

Melanoma is considered a masquerader of many diseases owing to its potential to metastasize to many organs. Several malignancies can metastasize to the heart including malignant melanoma. Historically, antemortem diagnosis of cardiac involvement of melanoma is not common, but with significant improvement in imaging modalities, the diagnosis can now be made early and accurately, aiding in treatment and improved survival. We present a case of a 36-year-old man with brief neurological symptoms and subsequent diagnosis of cerebrovascular accident (CVA). Cardiac imaging revealed incidental findings of right and left ventricular masses and lymph node biopsy, confirming metastatic melanoma. Cardioembolic etiology was suspected for his CVA. Prompt immunotherapy was initiated with improvement in his clinical condition.

Keywords: cardiac imaging; cardiac metastases; gene mutations; immunotherapy; melanoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. 2D echocardiogram, parasternal view showing multiple masses in the left ventricular (LV) cavity.
RV, Right ventricle
Figure 2
Figure 2. 2D echocardiogram, apical four-chamber view with masses in the left ventricular (LV) and right ventricular (RV) cavities.
Figure 3
Figure 3. 2D echocardiogram. Right ventricular (RV) cavity with a large mass.
Figure 4
Figure 4. Cardiac MRI, left ventricular (LV) and right ventricular (RV) melanomas (arrows).
Source: Ref. [8]

References

    1. The heart in malignant melanoma: a study of 70 autopsy cases. Glancy DL, Roberts WC. Am J Cardiol. 1968;21:555–571. - PubMed
    1. Metastatic melanoma of the heart: a systematic review. Balinski AM, Kerndt KC, Parry NP, Rehman R, Yeow R, Hayek S. J Clin Oncol. 2020;38:15_suppl, e22017.
    1. Metastatic involvement of the heart and pericardium: CT and MR imaging. Chiles C, Woodard PK, Gutierrez FR, Link KM. Radiographics. 2001;21:439–449. - PubMed
    1. Cardiac tumors--diagnosis and surgical treatment. Hoffmeier A, Sindermann JR, Scheld HH, Martens S. Dtsch Arztebl Int. 2014;111:205–211. - PMC - PubMed
    1. Novel mechanisms and therapeutic approaches in melanoma: targeting the MAPK pathway. Grimaldi AM, Simeone E, Festino L, et al. https://pubmed.ncbi.nlm.nih.gov/26175403/ Discov Med. 2015;19:455–461. - PubMed

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