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[Preprint]. 2023 Sep 18:2023.09.17.23295681.
doi: 10.1101/2023.09.17.23295681.

Sharing and Reusing Computable Phenotype Definitions

Shyam Visweswaran  1   2 , Louisa Yu Zhang  3 , Kevin Bui  1 , Eugene M Sadhu  1 , Malarkodi J Samayamuthu  1 , Michele M Morris  1
Affiliations

Sharing and Reusing Computable Phenotype Definitions

Shyam Visweswaran et al. medRxiv. .

Abstract

Background: A scalable approach for the sharing and reuse of human-readable and computer-executable phenotype definitions can facilitate the reuse of electronic health records for cohort identification and research studies.

Description: We developed a tool called Sharephe for the Informatics for Integrating Biology and the Bedside (i2b2) platform. Sharephe consists of a plugin for i2b2 and a cloud-based searchable repository of computable phenotypes, has the functionality to import to and export from the repository, and has the ability to link to supporting metadata.

Discussion: The i2b2 platform enables researchers to create, evaluate, and implement phenotypes without knowing complex query languages. In an initial evaluation, two sites on the Evolve to Next-Gen ACT (ENACT) network used Sharephe to successfully create, share, and reuse phenotypes.

Conclusion: The combination of a cloud-based computable repository and an i2b2 plugin for accessing the repository enables investigators to store and retrieve phenotypes from anywhere and at any time and to collaborate across sites in a research network.

Keywords: clinical data warehouse; cohort identification; computable phenotype; electronic health record.

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Figures

Figure 1.
Figure 1.
Sharephe plugin displaying phenotypes in the cloud-based repository.
Figure 2.
Figure 2.
Sharephe website displaying phenotypes in the cloud-based repository.
Figure 3.
Figure 3.
Sharephe plugin displaying a workbook.
Figure 4.
Figure 4.
Sharephe plugin displaying details of a query.
Figure 5.
Figure 5.
Architecture of the Sharephe plugin.
See this image and copyright information in PMC

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