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Review
. 2023 Oct 6;9(40):eadk5668.
doi: 10.1126/sciadv.adk5668. Epub 2023 Oct 4.

Evidence of immune imprinting or the effect of selection bias?

Christian H Hansen  1   2
Affiliations
Review

Evidence of immune imprinting or the effect of selection bias?

Christian H Hansen. Sci Adv. .

Abstract

People with booster vaccinations appear more prone to reinfection than those with primary series vaccination only; however, selection bias in the study design complicates interpretation.

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Figures

Fig. 1.
Fig. 1.. Study design comparing rates of reinfection among people with booster vaccinations and people with primary series vaccination only.
Because of the nonrandomized design, individuals who experienced a primary infection in the three-dose group, shortly after their booster dose, are more susceptible to infection than their counterparts in the two-dose group. Illustration credit: Ashley Mastin/Science Advances.
See this image and copyright information in PMC

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