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Comment
. 2023 Oct 3;35(10):1675-1676.
doi: 10.1016/j.cmet.2023.09.003.

Death-seq and ye shall find: A novel screening strategy for dying cells

Ryan Wallis  1 , Cleo L Bishop  2
Affiliations
Comment

Death-seq and ye shall find: A novel screening strategy for dying cells

Ryan Wallis et al. Cell Metab. .

Abstract

Killing senescent cells to improve health-span holds great promise. However, screening for senescence-regulating genes and molecules is challenging because these cells do not proliferate. In this issue, Colville and Liu et al. develop Death-seq, a positive selection screening tool that overcomes this hurdle to offer broad genetic and pharmacological utility.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Death-seq identifies regulators of cell death and senolytic therapies.
    Colville A, Liu JY, Rodriguez-Mateo C, Thomas S, Ishak HD, Zhou R, Klein JDD, Morgens DW, Goshayeshi A, Salvi JS, Yao D, Spees K, Dixon SJ, Liu C, Rhee JW, Lai C, Wu JC, Bassik MC, Rando TA. Colville A, et al. Cell Metab. 2023 Oct 3;35(10):1814-1829.e6. doi: 10.1016/j.cmet.2023.08.008. Epub 2023 Sep 11. Cell Metab. 2023. PMID: 37699398 Free PMC article.

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