Microbial-host isozyme: A novel target in "drug the bug" strategies for diabetes

Guojun Wu¹, Naisi Zhao², Liping Zhao³

Affiliations

¹ Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences and Center for Microbiome, Nutrition, and Health, New Jersey Institute for Food, Nutrition, and Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; Rutgers-Jiaotong Joint Laboratory for Microbiome and Human Health, New Brunswick, NJ, USA.
² Department of Public Health and Community Medicine, School of Medicine, Tufts University, Boston, MA 02111, USA.
³ Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences and Center for Microbiome, Nutrition, and Health, New Jersey Institute for Food, Nutrition, and Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; Rutgers-Jiaotong Joint Laboratory for Microbiome and Human Health, New Brunswick, NJ, USA. Electronic address: liping.zhao@rutgers.edu.

PMID: 37793343
DOI: 10.1016/j.cmet.2023.09.008

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Microbial-host isozyme: A novel target in "drug the bug" strategies for diabetes

Guojun Wu et al. Cell Metab. 2023.

Free article

. 2023 Oct 3;35(10):1677-1679.

doi: 10.1016/j.cmet.2023.09.008.

Authors

Guojun Wu¹, Naisi Zhao², Liping Zhao³

Affiliations

¹ Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences and Center for Microbiome, Nutrition, and Health, New Jersey Institute for Food, Nutrition, and Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; Rutgers-Jiaotong Joint Laboratory for Microbiome and Human Health, New Brunswick, NJ, USA.
² Department of Public Health and Community Medicine, School of Medicine, Tufts University, Boston, MA 02111, USA.
³ Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences and Center for Microbiome, Nutrition, and Health, New Jersey Institute for Food, Nutrition, and Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; Rutgers-Jiaotong Joint Laboratory for Microbiome and Human Health, New Brunswick, NJ, USA. Electronic address: liping.zhao@rutgers.edu.

PMID: 37793343
DOI: 10.1016/j.cmet.2023.09.008

Abstract

The role of the gut microbiome in metabolic diseases, such as diabetes, has emerged as a pivotal area of medical research. Wang et al.'s recent work reported that a gut bacteria-derived microbial-host isozyme, mimicking a human enzyme responsible for blood glucose regulation, can significantly impact the efficacy of diabetes medications.

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Conflict of interest statement

Declaration of interests L.Z. is a co-founder of Notitia Biotechnologies Company.

Comment on

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.
Wang K, Zhang Z, Hang J, Liu J, Guo F, Ding Y, Li M, Nie Q, Lin J, Zhuo Y, Sun L, Luo X, Zhong Q, Ye C, Yun C, Zhang Y, Wang J, Bao R, Pang Y, Wang G, Gonzalez FJ, Lei X, Qiao J, Jiang C. Wang K, et al. Science. 2023 Aug 4;381(6657):eadd5787. doi: 10.1126/science.add5787. Epub 2023 Aug 4. Science. 2023. PMID: 37535747

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Microbial-host isozyme: A novel target in "drug the bug" strategies for diabetes

Affiliations

Microbial-host isozyme: A novel target in "drug the bug" strategies for diabetes

Authors

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Abstract

Conflict of interest statement

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Medical

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