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. 2023 Oct 21;44(40):4288-4291.
doi: 10.1093/eurheartj/ehad630.

Auditory stimulation of sleep slow waves enhances left ventricular function in humans

Stephanie Huwiler  1 , Manuel Carro-Domínguez  1 , Fabia M Stich  1 , Rossella Sala  1 , Florent Aziri  1 , Anna Trippel  1 , Tabea Ryf  2 , Susanne Markendorf  2 , David Niederseer  2 , Philipp Bohm  2 , Gloria Stoll  1 , Lily Laubscher  1 , Jeivicaa Thevan  3 , Christina M Spengler  4   5 , Joanna Gawinecka  3 , Elena Osto  3 , Reto Huber  6   7   8   9 , Nicole Wenderoth  1   7   10 , Christian Schmied  2 , Caroline Lustenberger  1   6   7
Affiliations

Auditory stimulation of sleep slow waves enhances left ventricular function in humans

Stephanie Huwiler et al. Eur Heart J. .
No abstract available

Keywords: Auditory stimulation; Blood pressure; Echocardiography; Left ventricular function; Sleep slow waves; Strain imaging.

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Figures

Figure 1
Figure 1
(A) Study protocol of clinical trial: the study started with a screening phase where the eligibility of participants was checked by an initial phone screening followed by a screening night in the sleep laboratory. If all inclusion/exclusion criteria were fulfilled, participants were invited to a cardiovascular screening to verify the absence of any cardiovascular disease. Afterwards, the experimental phase including three experimental nights took place. Three days prior to each experimental night, a compliance phase started where participants had to adhere to a regular sleep/wake schedule. The intervention conditions were administered in a pseudo-randomized order. (B) Topographical distribution of low slow wave activity (0.5–2.0 Hz) ON–OFF difference within the stimulation windows of the nights of the conditions ISI1High, ISI1Low, and SHAM. Highlighted dots indicate significant electrodes (P < .05) for the post hoc P-values applying linear-mixed effects models with condition entered as fixed factor and subject as random factor compared with the SHAM condition. P-values for each topoplot have been corrected for multiple comparisons by applying the false discovery rate. (C) Time course of relative instantaneous heart rate during the stimulation window for the conditions ISI1High, ISI1Low, and SHAM. Relative instantaneous heart rate change was calculated based on a two-beat heart rate baseline prior to the stimulation window. (D) Time course of the relative change of systolic blood pressure during the stimulation window. Relative blood pressure change was calculated based on a two-beat baseline prior to the stimulation window. (E–G) Post-sleep echocardiographic parameters presented as mean ± standard error of the mean. P-values have been computed based on a linear mixed-effect model with the fixed factor condition and random factor subject and were corrected for multiple comparisons by applying the Hochberg method. (E) Echo-strain: global longitudinal strain. F(2,34) = 81.169, P < .001. (F) LV EF: Left ventricular ejection fraction. F(2,34) = 4.547, P = .018. (G) E/eʹ: left ventricular filling pressure. F(2,34) = 3.382, P = .046. All data are shown for 18 participants. ***P < .001, **P < .01, *P < .05.
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References

    1. Grandner MA, Alfonso-Miller P, Fernandez-Mendoza J, Shetty S, Shenoy S, Combs D. Sleep: important considerations for the prevention of cardiovascular disease. Curr Opin Cardiol 2016;31:551–65. 10.1097/HCO.0000000000000324 - DOI - PMC - PubMed
    1. Huwiler S, Carro Dominguez M, Huwyler S, Kiener L, Stich FM, Sala R, et al. . Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics. Sleep 2022;45:zsac155. 10.1093/sleep/zsac155 - DOI - PMC - PubMed
    1. Lustenberger C, Ferster ML, Huwiler S, Brogli L, Werth E, Huber R, et al. . Auditory deep sleep stimulation in older adults at home: a randomized crossover trial. Commun Med (Lond) 2022;2:30. 10.1038/s43856-022-00096-6 - DOI - PMC - PubMed
    1. Iber C, Ancoli-Israel S, Chesson A, Quan S. The AASM Manual for the Scoring of Sleep and Associated Events—Rules Terminology and Technical Specifications. Westchester: American Academy of Sleep Medicine, 2007.
    1. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. . Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. Deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012;8:597–619. 10.5664/jcsm.2172 - DOI - PMC - PubMed

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