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Comparative Study
. 1986 Sep;32(9):738-42.

[Effect of amphotericin B on the sterol composition of Kluyveromyces bulgaricus and Kluyveromyces lactis]

[Article in French]
J Coulon, A Hakkou, M Mpona-Minga, R Bonaly
  • PMID: 3779526
Comparative Study

[Effect of amphotericin B on the sterol composition of Kluyveromyces bulgaricus and Kluyveromyces lactis]

[Article in French]
J Coulon et al. Can J Microbiol. 1986 Sep.

Abstract

The degree of sensitivity of the yeasts Kluyveromyces bulgaricus and K. lactis to amphotericin B is linked to a difference in the sterol composition of their membranes. No direct proportionality was found between sensitivity and the quantity of sterols present. At sublethal doses, amphotericin B perturbed sterol synthesis, resulting in ergosterol precursor accumulation. An ergosterol pathway is proposed for Kluyveromyces.

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