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. 2023;45(2):2264977.
doi: 10.1080/0886022X.2023.2264977. Epub 2023 Oct 5.

Outcomes of elderly peritoneal dialysis patients: 65-74 years old versus ≥ 75 years old

Luyan Gao  1 , Xuefeng Chen  1 , Sheng Feng  1 , Ying Lu  1 , Kai Song  1 , Huaying Shen  1 , Yun Wang  1 , Linsen Jiang  1 , Zhi Wang  1
Affiliations

Outcomes of elderly peritoneal dialysis patients: 65-74 years old versus ≥ 75 years old

Luyan Gao et al. Ren Fail. 2023.

Abstract

Objective: To analyze the clinical data of elderly patients with peritoneal dialysis (PD) and compare patient and technique survival rates between Group 1 (65-74 years old) and Group 2 (≥75 years old).

Methods: This retrospective study enrolled 296 elderly patients (≥65 years old) on maintenance PD who were admitted to the Peritoneal Dialysis Center of the Second Hospital of Soochow University. The patients were categorized by outcome into ongoing PD, changed to hemodialysis, renal recovery dialysis stopped, or death groups. The patients were divided into Group 1 (65-74 years old) and Group 2 (≥75 years old). Patient survival and technique survival rates were calculated by the Kaplan-Meier method. Factors associated with patient survival were analyzed using the Cox regression model.

Results: There were 176 (59.5%) subjects in Group 1 and 120 (40.5%) subjects in Group 2. The primary causes of death were cardiovascular events, peritonitis, and other infections. The patient survival rates at 1, 3, and 5 years were 91.2%, 68.0%, and 51.3% in Group 1 and 76.8%, 37.5%, and 17.6% in Group 2 (p < 0.001, HR 0.387, 95% CI 0.282-0.530). There was no statistically significant difference in the technique survival rate between the two groups (p = 0.54).

Conclusion: The elderly PD patients in this cohort mostly died from cardiovascular events, with a higher patient survival rate in Group 1 and similar technique survival in both groups. Older age, lower prealbumin, higher creatinine, not being on activated vitamin D, and high Charlson's comorbidity index (CCI) score were independent risk factors for death.

Keywords: 65–74 years old versus ≥75 years old; Peritoneal dialysis; patient survival; technical survival.

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Conflict of interest statement

Luyan Gao and Xuefeng Chen contributed equally to this article. Linsen Jiang and Zhi Wang are the corresponding authors. We certify that all authors have no financial or other conflicts of interest connected with the submitted article.

Figures

Figure 1.
Figure 1.
Flow chart for eligible patients.
Figure 2.
Figure 2.
Patient survival rate.
Figure 3.
Figure 3.
Technique survival rate among surviving subjects.
Figure 4.
Figure 4.
Patient survival curves for both groups (p < 0.001, HR 0.387, 95% CI 0.282–0.530).
Figure 5.
Figure 5.
Technique survival curves for both groups (p = 0.54, HR 0.792, 95% CI 0.396–1.584).
See this image and copyright information in PMC

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