Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Oct;124(10):1449-1465.
doi: 10.1002/jcb.30477. Epub 2023 Oct 5.

Regulation of cholesterol metabolism: New players for an old physiological process

Martina Parente  1 , Claudia Tonini  1 , Marco Segatto  2 , Valentina Pallottini  1   3
Affiliations
Review

Regulation of cholesterol metabolism: New players for an old physiological process

Martina Parente et al. J Cell Biochem. 2023 Oct.

Abstract

Identified more than two centuries ago, cholesterol plays a pivotal role in human physiology. Since cholesterol metabolism is a physiologically significant process, it is not surprising that its alterations are associated with several pathologies. The discovery of new molecular targets or compounds able to modulate this sophisticated metabolism has been capturing the attention of research groups worldwide since many years. Endogenous and exogenous compounds are known to regulate cellular cholesterol synthesis and uptake, or reduce cholesterol absorption at the intestinal level, thereby regulating cholesterol homeostasis. However, there is a great need of new modulators and diverse new pathways have been uncovered. Here, after illustrating cholesterol metabolism and its well-known regulators, some new players of this important physiological process are also described.

Keywords: BET proteins; HDACs; TMEM97; cholesterol; metabolism; neurotrophins.

PubMed Disclaimer

References

REFERENCES

    1. Yang S-T, Kreutzberger AJB, Lee J, Kiessling V, Tamm LK. The role of cholesterol in membrane fusion. Chem Phys Lipids. 2016;199:136-143. doi:10.1016/j.chemphyslip.2016.05.003
    1. Sezgin E, Levental I, Mayor S, Eggeling C. The mystery of membrane organization: composition, regulation and roles of lipid rafts. Nat Rev Mol Cell Biol. 2017;18(6):361-374. doi:10.1038/nrm.2017.16
    1. Goldstein JL, Brown MS. The cholesterol quartet. Science. 2001;292(5520):1310-1312. doi:10.1126/science.1061815
    1. Repa JJ, Liang G, Ou J, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14(22):2819-2830. doi:10.1101/gad.844900
    1. Trapani L, Segatto M, Simeoni V, et al. Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin. Biochimie. 2011;93(7):1165-1171. doi:10.1016/j.biochi.2011.04.009

Publication types

LinkOut - more resources