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Comment
. 2023 Dec 15;29(24):5002-5004.
doi: 10.1158/1078-0432.CCR-23-2259.

Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment

Christopher Kuo  1   2 , James F Amatruda  1   2   3
Affiliations
Comment

Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment

Christopher Kuo et al. Clin Cancer Res. .

Abstract

Cells in the tumor microenvironment, including cancer-associated fibroblasts (CAF), contribute to tumor growth and immune evasion. A recent study of Ewing sarcoma identified "CAF-like" tumor cells that mimic the protumorigenic features of CAFs. These findings highlight the role of cell plasticity in tumor growth. See related article by Wrenn et al., p. 5140.

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Conflict of interest statement

Disclosure: The authors declare no Conflict of Interest.

Figures

Figure 1:
Figure 1:. Contribution of CAF-like tumor cells to the tumor microenvironment.
Ewing sarcoma (EwS) tumors recruit immune cells and stromal cells including cancer-associated fibroblasts (CAFs). EwS cells with low activity of the EWSR1::FLI1 fusion oncogene enter a migratory, mesenchymal state. Wrenn et al. (1) identify tumor-derived “CAF-like” cells that maintain expression of EWSR1::FLI1-activated genes while mimicking pro-tumorigenic functions of CAFs. (Adapted from an image created with Biorender.com)
See this image and copyright information in PMC

Comment on

References

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