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. 2023 Sep-Oct;29(5):249-258.
doi: 10.1097/PPO.0000000000000682.

Hepatocellular Carcinoma Genetic Classification

Zurabi Lominadze  1 , Mohammed Rifat Shaik  2 , Dabin Choi  3 , Duha Zaffar  2 , Lopa Mishra  4 , Kirti Shetty  1
Affiliations

Hepatocellular Carcinoma Genetic Classification

Zurabi Lominadze et al. Cancer J. 2023 Sep-Oct.

Abstract

Hepatocellular carcinoma (HCC) represents a significant global burden, with management complicated by its heterogeneity, varying presentation, and relative resistance to therapy. Recent advances in the understanding of the genetic, molecular, and immunological underpinnings of HCC have allowed a detailed classification of these tumors, with resultant implications for diagnosis, prognostication, and selection of appropriate treatments. Through the correlation of genomic features with histopathology and clinical outcomes, we are moving toward a comprehensive and unifying framework to guide our diagnostic and therapeutic approach to HCC.

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Conflict of interest statement

Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Funding was provided by NIAAA R01AA023146 (to L.M.); NCI R01CA236591 (to L.M.); NCI U01CA230690 (to L.M. and K.S.).

Figures

Figure 1:
Figure 1:. Genetic events leading to HCC development in cirrhosis.
These may be classified as genomic ( somatic mutations and genome structure changes);epigenetic ( changes in methylation / chromatin modeling) and transcriptional
See this image and copyright information in PMC

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