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. 2023 Oct 5;19(10):e1011504.
doi: 10.1371/journal.ppat.1011504. eCollection 2023 Oct.

Prevention of zoonotic spillover: From relying on response to reducing the risk at source

Authored by the members of the One Health High-Level Expert Panel (OHHLEP); Wanda Markotter  1 , Thomas C Mettenleiter  2 , Wiku B Adisasmito  3 , Salama Almuhairi  4 , Casey Barton Behravesh  5 , Pépé Bilivogui  6 , Salome A Bukachi  7 , Natalia Casas  8 , Natalia Cediel Becerra  9 , Dominique F Charron  10 , Abhishek Chaudhary  11 , Janice R Ciacci Zanella  12 , Andrew A Cunningham  13 , Osman Dar  14   15 , Nitish Debnath  16 , Baptiste Dungu  17   18 , Elmoubasher Farag  19 , George F Gao  20 , David T S Hayman  21 , Margaret Khaitsa  22 , Marion P G Koopmans  23 , Catherine Machalaba  24 , John S Mackenzie  25 , Serge Morand  26 , Vyacheslav Smolenskiy  27 , Lei Zhou  20
Affiliations

Prevention of zoonotic spillover: From relying on response to reducing the risk at source

Authored by the members of the One Health High-Level Expert Panel (OHHLEP) et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Prevention of zoonotic spillover to humans: Prevention of pathogen spillover from animals to humans; shifting the infectious disease control paradigm from reactive to proactive (primary prevention, upstream).
Prevention includes addressing the drivers of disease emergence, namely ecological, meteorological, and anthropogenic factors and activities that increase spillover risk, in order to reduce the risk of human infection. It is informed by, among other actions, biosurveillance in domestic and wild animals, people and the environment, understanding pathogen infection dynamics, and implementing intervention activities. Exemplary preparedness-response actions (downstream actions) are indicated on the right.
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