Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair

Nicolas G Bazan¹, Jeff X Ji², Samuel E Baum²

Affiliations

¹ Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA. Electronic address: nbazan@lsuhsc.edu.
² Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.

PMID: 37797578
DOI: 10.1016/j.neuron.2023.08.020

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Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair

Nicolas G Bazan et al. Neuron. 2023.

Free article

. 2023 Oct 4;111(19):2945-2948.

doi: 10.1016/j.neuron.2023.08.020.

Authors

Nicolas G Bazan¹, Jeff X Ji², Samuel E Baum²

Affiliations

¹ Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA. Electronic address: nbazan@lsuhsc.edu.
² Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.

PMID: 37797578
DOI: 10.1016/j.neuron.2023.08.020

Abstract

In this issue of Neuron, Nakamura et al.¹ report the discovery that neuronally secreted phospholipase PLA2G2E releases dihomo-γ-linolenic acid (DGLA) that generates 15-hydroxy-eicosatrienoic acid (15-HETrE), which in turn induces peptidyl arginine deiminase 4 (PAD4/PADI4) to elicit neuronal pro-survival and pro-reparative events following ischemic brain injury.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke.
Nakamura A, Sakai S, Taketomi Y, Tsuyama J, Miki Y, Hara Y, Arai N, Sugiura Y, Kawaji H, Murakami M, Shichita T. Nakamura A, et al. Neuron. 2023 Oct 4;111(19):2995-3010.e9. doi: 10.1016/j.neuron.2023.06.024. Epub 2023 Jul 24. Neuron. 2023. PMID: 37490917

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Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair

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Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair

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