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Comment
. 2023 Oct 4;111(19):2948-2950.
doi: 10.1016/j.neuron.2023.09.011.

Endocannabinoids modulate fear extinction controlled by a cortical-amygdala projection

Avishek Adhikari  1
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Endocannabinoids modulate fear extinction controlled by a cortical-amygdala projection

Avishek Adhikari. Neuron. .
Free article

Abstract

The projection from the medial prefrontal cortex to the amygdala is a key node in fear extinction. In this issue of Neuron, Gunduz-Cinar et al.1 show that extinction induction by this projection requires recruitment of endocannabinoids (eCBs) in the amygdala.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction.
    Gunduz-Cinar O, Castillo LI, Xia M, Van Leer E, Brockway ET, Pollack GA, Yasmin F, Bukalo O, Limoges A, Oreizi-Esfahani S, Kondev V, Báldi R, Dong A, Harvey-White J, Cinar R, Kunos G, Li Y, Zweifel LS, Patel S, Holmes A. Gunduz-Cinar O, et al. Neuron. 2023 Oct 4;111(19):3053-3067.e10. doi: 10.1016/j.neuron.2023.06.023. Epub 2023 Jul 21. Neuron. 2023. PMID: 37480845 Free PMC article.

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