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Review
. 2024 Jan;21(1):7-24.
doi: 10.1038/s41575-023-00840-w. Epub 2023 Oct 5.

Therapeutic developments in pancreatic cancer

Z Ian Hu  1 , Eileen M O'Reilly  2   3
Affiliations
Review

Therapeutic developments in pancreatic cancer

Z Ian Hu et al. Nat Rev Gastroenterol Hepatol. 2024 Jan.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most lethal human malignancies. Much is known regarding the biology and pathophysiology of PDAC, but translating this knowledge to the clinic to improve patient outcomes has been challenging. In this Review, we discuss advances and practice-changing trials for PDAC. We briefly review therapeutic failures as well as ongoing research to refine the standard of care, including novel biomarkers and clinical trial designs. In addition, we highlight contemporary areas of research, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies and immunotherapies. Finally, we discuss the future of pancreatic cancer research and areas for improvement in the next decade.

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References

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