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Review
. 2023 Sep 20:11:1235716.
doi: 10.3389/fcell.2023.1235716. eCollection 2023.

Emerging roles of proximal tubular endocytosis in renal fibrosis

Min Chen  1 , Xiangchen Gu  1   2   3
Affiliations
Review

Emerging roles of proximal tubular endocytosis in renal fibrosis

Min Chen et al. Front Cell Dev Biol. .

Abstract

Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority of filtered water and glucose, as well as all the proteins filtered through the glomerular barrier via endocytosis, indicating an essential role in kidney diseases. Genetic mutations or acquired insults could affect the proximal tubule endocytosis processes, by disturbing or overstressing the endolysosomal system and subsequently activating different pathways, orchestrating renal fibrosis. This paper will review recent studies on proximal tubular endocytosis affected by other diseases and factors. Endocytosis plays a vital role in the development of renal fibrosis, and renal fibrosis could also, in turn, affect tubular endocytosis.

Keywords: cubulin; endocytosis; megalin; renal fibrosis; tubule epithelial cell.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Genetic mutations or acquired insults affect tubular endocytosis, leading to renal fibrosis.
See this image and copyright information in PMC

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