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Review
. 2023 Sep 20:13:1263347.
doi: 10.3389/fonc.2023.1263347. eCollection 2023.

Diagnostic challenges and prognostic implications of extranodal extension in head and neck cancer: a state of the art review and gap analysis

Christina E Henson  1 , Ahmad K Abou-Foul  2 , Daniel J Morton  3 , Lachlan McDowell  4 , Sujith Baliga  5 , James Bates  6 , Anna Lee  7 , Pierluigi Bonomo  8 , Petr Szturz  9 , Paul Nankivell  2 , Shao Hui Huang  10 , William M Lydiatt  11 , Brian O'Sullivan  10 , Hisham Mehanna  2
Affiliations
Review

Diagnostic challenges and prognostic implications of extranodal extension in head and neck cancer: a state of the art review and gap analysis

Christina E Henson et al. Front Oncol. .

Abstract

Extranodal extension (ENE) is a pattern of cancer growth from within the lymph node (LN) outward into perinodal tissues, critically defined by disruption and penetration of the tumor through the entire thickness of the LN capsule. The presence of ENE is often associated with an aggressive cancer phenotype in various malignancies including head and neck squamous cell carcinoma (HNSCC). In HNSCC, ENE is associated with increased risk of distant metastasis and lower rates of locoregional control. ENE detected on histopathology (pathologic ENE; pENE) is now incorporated as a risk-stratification factor in human papillomavirus (HPV)-negative HNSCC in the eighth edition of the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) TNM classification. Although ENE was first described almost a century ago, several issues remain unresolved, including lack of consensus on definitions, terminology, and widely accepted assessment criteria and grading systems for both pENE and ENE detected on radiological imaging (imaging-detected ENE; iENE). Moreover, there is conflicting data on the prognostic significance of iENE and pENE, particularly in the context of HPV-associated HNSCC. Herein, we review the existing literature on ENE in HNSCC, highlighting areas of controversy and identifying critical gaps requiring concerted research efforts.

Keywords: extranodal extension; head and neck cancer; head and neck pathology; head and neck squamous cell carcinoma; locally advanced head and neck cancer.

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Conflict of interest statement

HM reports grants from UK National Institute of Health research, Cancer Research UK, the UK Medical Research Council, and AstraZeneca; advisory board fees from AstraZeneca, MSD, Merck, Nanobiotix, and Seagen; and is Director of Warwickshire head neck clinic and Docpsert Health. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Depiction of various extents of lymph node involvement with tumor (Created in Biorender.com).
Figure 2
Figure 2
Contrasted axial (A) and sagittal (B) CT scans of a patient with clear ENE (Images kindly provided by Dr. Santiago Medrano).
Figure 3
Figure 3
Pattern/Grade of radiologically imaged ENE – depicting the extent of image-identified ENE (iENE) based on Hoebers et al. (28) and Chin et al. (29) (Images kindly provided by Dr. Eugene Yu).
Figure 4
Figure 4
(A) Axial T2-weighted MRI showing a coalescent right level II nodal mass suspicious for iENE. (B) Axial T2-weighted MRI with a large L level III nodal mass with clear invasion of the sternocleidomastoid and extension into overlying subcutaneous fat and skin. (Images kindly provided by Dr. Eugene Yu).
Figure 5
Figure 5
(A) Contrasted axial CT scan of a patient with a L level II node suspicious for iENE, which was later confirmed pathologically. (B) Contrasted axial CT scan of a patient with a R level II node suspicious for iENE, but ENE was not found on pathology. (Images kindly provided by Dr. James Bates).
See this image and copyright information in PMC

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