Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov;64(6):1099-1102.
doi: 10.1111/vru.13303. Epub 2023 Oct 6.

Intensity-modulated radiotherapy and chemotherapy for canine right atrial tumors: A retrospective study of seven dogs

Steven Moirano  1 , Michelle Turek  1 , Diana Sanchez  2 , David Vail  2 , Nate Van Asselt  1 , Jessica Lawrence  3 , Lisa Forrest  1
Affiliations

Intensity-modulated radiotherapy and chemotherapy for canine right atrial tumors: A retrospective study of seven dogs

Steven Moirano et al. Vet Radiol Ultrasound. 2023 Nov.

Abstract

Most primary cardiac tumors in dogs are located in the right atrium/atrial appendage, with hemangiosarcoma being the most common. The aims of this retrospective, case series were to describe outcomes for seven dogs with right atrial tumors treated with hypofractionated intensity-modulated radiotherapy and concurrent vinblastine and propranolol. One dog had a complete response, four dogs had partial responses and two dogs had stable disease after treatment. Effusions resolved in all dogs. Median progression-free survival was 290 days. Five dogs died from metastatic disease, one dog from unrelated neoplasia, and one dog is alive. Median overall survival was 326 days. Three dogs with confirmed hemangiosarcoma survived 244, 326, and 445 days. Two dogs developed clinically significant, but nonfatal, cardiac arrhythmias. One dog that received three courses of radiation had subclinical myocardial and arterial fibrosis at necropsy. Hypofractionated chemoradiotherapy was well tolerated and may provide clinical benefit in dogs with right atrial tumors.

Keywords: cancer; cardiac; hemangiosarcoma; propranolol; vinblastine.

PubMed Disclaimer

References

REFERENCES

    1. Ware WA, Hopper DL. Cardiac tumors in dogs: 1982-1995. J Vet Intern Med. 1999; 13:95-103.
    1. Yamamoto S, Hoshi K, Hirakawa A, Chimura S, Kobayashi M, Machida N. Epidemiological, clinical and pathological features of primary cardiac hemangiosarcoma in dogs: a review of 51 cases. J Vet Med Sci. 2013; 75:1433-1441.
    1. Mullin CM, Arkans MA, Sammarco CD, et al. Doxorubicin chemotherapy for presumptive cardiac hemangiosarcoma in dogs†. Vet Comp Oncol. 2016; 14:e171-183.
    1. Weisse C, Soares N, Beal MW, Steffey MA, Drobatz KJ, Henry CJ. Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy: 23 cases (1986-2000). J Am Vet Med Assoc. 2005; 226:575-579.
    1. Nolan MW, Arkans MM, LaVine D, et al. Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion. J Vet Cardiol. 2017; 19:132-143.

LinkOut - more resources