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Review
. 2023 Dec:370:114562.
doi: 10.1016/j.expneurol.2023.114562. Epub 2023 Oct 5.

Alterations in neurotransmitter co-release in Parkinson's disease

Kelsey Barcomb  1 , Christopher P Ford  2
Affiliations
Review

Alterations in neurotransmitter co-release in Parkinson's disease

Kelsey Barcomb et al. Exp Neurol. 2023 Dec.

Abstract

Parkinson's disease is a neurological disorder characterized by degeneration of midbrain dopamine neurons, which results in numerous adaptations in basal ganglia circuits. Research over the past twenty-five years has identified that midbrain dopamine neurons of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) co-release multiple other transmitters including glutamate and GABA, in addition to their canonical transmitter, dopamine. This review summarizes previous work characterizing neurotransmitter co-release from dopamine neurons, work examining potential changes in co-release dynamics that result in animal models of Parkinson's disease, and future opportunities for determining how dysfunction in co-release may contribute to circuit dysfunction in Parkinson's disease.

Keywords: Basal ganglia; Co-release; Dopamine; GABA; Glutamate; Parkinson's; Striatum.

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Conflict of interest statement

Declaration of Competing Interest None.

Figures

Fig. 1.
Fig. 1.
Potential alterations in co-release in Parkinson’s disease.
See this image and copyright information in PMC

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