A Review of Computational Approach for S-system-based Modeling of Gene Regulatory Network

Abstract

Inference of gene regulatory network (GRN) from time series microarray data remains as a fascinating task for computer science researchers to understand the complex biological process that occurred inside a cell. Among the different popular models to infer GRN, S-system is considered as one of the promising non-linear mathematical tools to model the dynamics of gene expressions, as well as to infer the GRN. S-system is based on biochemical system theory and power law formalism. By observing the value of kinetic parameters of S-system model, it is possible to extract the regulatory relationships among genes. In this review, several existing intelligent methods that were already proposed for inference of S-system-based GRN are explained. It is observed that finding out the most suitable and efficient optimization technique for the accurate inference of all kinds of networks, i.e., in-silico, in-vivo, etc., with less computational complexity is still an open research problem to all. This paper may help the beginners or researchers who want to continue their research in the field of computational biology and bioinformatics.

Keywords: Bio-chemical system theory; Cardinality; Decoupling; Gene regulatory network; Microarray data; Optimization; Power law function; Regularization; S-system.