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Review
. 2023 Dec:77:102400.
doi: 10.1016/j.cbpa.2023.102400. Epub 2023 Oct 5.

Nutritional metabolomics: Recent developments and future needs

Maaria Kortesniemi  1 , Stefania Noerman  2 , Anna Kårlund  3 , Jasmin Raita  3 , Topi Meuronen  3 , Ville Koistinen  4 , Rikard Landberg  2 , Kati Hanhineva  4
Affiliations
Free article
Review

Nutritional metabolomics: Recent developments and future needs

Maaria Kortesniemi et al. Curr Opin Chem Biol. 2023 Dec.
Free article

Abstract

Metabolomics has rapidly been adopted as one of the key methods in nutrition research. This review focuses on the recent developments and updates in the field, including the analytical methodologies that encompass improved instrument sensitivity, sampling techniques and data integration (multiomics). Metabolomics has advanced the discovery and validation of dietary biomarkers and their implementation in health research. Metabolomics has come to play an important role in the understanding of the role of small molecules resulting from the diet-microbiota interactions when gut microbiota research has shifted towards improving the understanding of the activity and functionality of gut microbiota rather than composition alone. Currently, metabolomics plays an emerging role in precision nutrition and the recent developments therein are discussed.

Keywords: Biomarker; Dietary pattern; Endogenous metabolite; Gut microbiota; Metabolomics; Nutrition; Precision prevention.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships that may be considered as potential competing interests: Kati Hanhineva reports a relationship with Afekta Technologies that includes: board membership, employment, and equity or stocks. Ville Koistinen reports a relationship with Afekta Technologies that includes: board membership, employment, and equity or stocks. Topi Meuronen reports a relationship with Afekta Technologies that includes: consulting or advisory and paid expert testimony.

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