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. 2023 Dec:116:102812.
doi: 10.1016/j.ceca.2023.102812. Epub 2023 Sep 29.

Pentameric TRPV3: An artifact or a clue to channel function?

Arthur Neuberger  1 , Alexander I Sobolevsky  2
Affiliations

Pentameric TRPV3: An artifact or a clue to channel function?

Arthur Neuberger et al. Cell Calcium. 2023 Dec.
No abstract available

Keywords: 2-APB; AFM; Cryo-EM; DPBA; Pentamer; TRP channel; TRPV3; Tetramer.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.. TRPV3 tetramer versus pentamer.
a, TRPV3 tetramer (PDB ID: 8GKA) with swapped domain arrangement. b-c, TRPV3 pentamer (PDB ID: 8GKG) with subunits colored according to swapped (b) and non-swapped (c) domain arrangement.
See this image and copyright information in PMC

References

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    1. Lansky S. et al. A pentameric TRPV3 channel with a dilated pore. Nature 621, 206–214, doi:10.1038/s41586-023-06470-1 (2023). - DOI - PMC - PubMed
    1. Singh AK, McGoldrick LL & Sobolevsky AI Structure and gating mechanism of the transient receptor potential channel TRPV3. Nat Struct Mol Biol 25, 805–813, doi:10.1038/s41594-018-0108-7 (2018). - DOI - PMC - PubMed
    1. Zubcevic L, Borschel WF, Hsu AL, Borgnia MJ & Lee SY Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Elife 8, doi:10.7554/eLife.47746 (2019). - DOI - PMC - PubMed

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