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Comment
. 2023 Nov;44(11):874-876.
doi: 10.1016/j.it.2023.09.006. Epub 2023 Oct 5.

Monoclonal antibodies lock down SARS-CoV-2 spike

Hsiang-Chi Huang  1 , Davide Angeletti  2
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Comment

Monoclonal antibodies lock down SARS-CoV-2 spike

Hsiang-Chi Huang et al. Trends Immunol. 2023 Nov.
Free article

Abstract

SARS-CoV-2 rapidly accumulated mutations in its immunodominant receptor-binding domain (RBD), rendering all clinically authorized monoclonal antibodies (mAbs) ineffective. Liu et al. unveil potent human mAbs that neutralize all tested SARS-CoV-2 variants by locking the Spike protein RBD in a downward conformation, thus inhibiting receptor engagement.

Keywords: Omicron; SARS-CoV-2; broadly neutralizing antibody; cryo-EM; monoclonal antibodies.

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Declaration of interests No interests are declared.

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