Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct 7;23(1):664.
doi: 10.1186/s12879-023-08581-6.

Catheter-Related Bloodstream Infections among patients on maintenance haemodialysis: a cross-sectional study at a tertiary hospital in Ghana

Bismark Opoku-Asare  1 , Vincent Boima  1   2 , Vincent Jessey Ganu  1 , Elvis Aboagye  3 , Olive Asafu-Adjaye  4 , Anita Ago Asare  5 , Isaac Kyeremateng  6 , Edward Kwakyi  1   2 , Adwoa Agyei  1   2 , Eric Sampane-Donkor  7 , Peter Puplampu  8   9
Affiliations

Catheter-Related Bloodstream Infections among patients on maintenance haemodialysis: a cross-sectional study at a tertiary hospital in Ghana

Bismark Opoku-Asare et al. BMC Infect Dis. .

Abstract

Background: Catheter-Related Bloodstream Infections (CRBSIs) are notable complications among patients receiving maintenance haemodialysis. However, data on the prevalence of CRBSIs is lacking. This study was conducted to determine the prevalence and factors associated with CRBSIs among patients receiving haemodialysis in the renal unit of the largest tertiary hospital in Ghana.

Methods: A hospital-based cross-sectional study was conducted on patients receiving maintenance haemodialysis via central venous catheters (CVC) between September 2021 and April 2022. Multivariate analysis using logistic regression was used to determine the risk factors that were predictive of CRBSI. Analysis was performed using SPSS version 23 and a p-value<0.05 was statistically significant.

Results: The prevalence of CRBSI was 34.2% (52/152). Of these, more than half of them (53.9%(28/52)) had Possible CRBSI while 11.5% (6/52) had Definite CRBSI. Among the positive cultures, 62% (21/34) were from catheter sites whilst the rest were from peripheral blood. Gram-negative cultures made up 53% (18/34) of positive cultures with the rest being Gram positive cultures. Acinetobacter baumannii (33.3% (6/18)) was the commonest organism isolated among Gram-negative cultures whilst Coagulase negative Staphylococci (43.7% (7/16)) was the commonest organism isolated among Gram-positve cultures. Gram-negative bacilli were more predominant in this study making up 52.9% of the total bacteria cultured. Sex, duration of maintenance dialysis, underlying cause of End-stage kidney disease, mean corpuscular haemoglobin (MCH), neutrophil count and lymphocyte count were significantly predictive of CRBSI status (p<0.05).

Conclusion: There was a high prevalence of CRBSI among patients undergoing haemodialysis. The commonest causative agent was Coagulase negative Staphylococci, however there was a predominance of Gram-negative bacilli as compared to Gram positive cocci. There is a need to set up infection surveillance unit in the renal unit to track CRBSI and put in place measures to reduce these CRBSI.

Keywords: Catheter-related bloodstream infections; Central venous catheter; Haemodialysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart for patients recruited into the study
Fig. 2
Fig. 2
Classification of CRBSI among study participants at the Korle Bu Teaching Hospital, Accra, Ghana, 2021-2022.
See this image and copyright information in PMC

References

    1. Hallan SI, Coresh J, Astor BC, Åsberg A, Powe NR, Romundstad S, et al. International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J Am Soc Nephrol. 2006;17(8):2275–84. doi: 10.1681/ASN.2005121273. - DOI - PubMed
    1. Eriksen BO, Ingebretsen OC. The progression of chronic kidney disease: a 10-year population-based study of the effects of gender and age. Kidney Int. 2006;69(2):375–82. doi: 10.1038/sj.ki.5000058. - DOI - PubMed
    1. Adjei DN, Stronks K, Adu D, Beune E, Meeks K, Smeeth L, et al. Chronic kidney disease burden among African migrants in three European countries and in urban and rural Ghana: the RODAM cross-sectional study. Nephrol Dial Transplant. 2018;33(10):1812–22. doi: 10.1093/ndt/gfx347. - DOI - PubMed
    1. Wang L, Wei F, Jiang A, Chen H, Sun G, Bi X. Longer duration of catheter patency, but similar infection rates with internal jugular vein versus iliac vein tunneled cuffed haemodialysis catheters: a single-center retrospective analysis. Int Urol Nephrol. 2015;47(10):1727–34. doi: 10.1007/s11255-015-1089-7. - DOI - PubMed
    1. Santoro D, Benedetto F, Mondello P, Pipitò N, Barillà D, Spinelli F, et al. Vascular access for haemodialysis: current perspectives. Taylor Fr. 2014;7:281–94. - PMC - PubMed

LinkOut - more resources