Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 20;39(7):679-684.
doi: 10.3760/cma.j.cn501225-20230320-00086.

[Research advances of sepsis biomarkers]

[Article in Chinese]
Z Zeng  1 , Y Z Peng  1 , Z Q Yuan  1
Affiliations
Review

[Research advances of sepsis biomarkers]

[Article in Chinese]
Z Zeng et al. Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. .

Abstract
in English, Chinese

Sepsis is a life-threatening condition for patients. Biomarkers can be used for the diagnosis, treatment, and prognostic assessment of sepsis. In recent years, new biomarkers for sepsis have been discovered, and more than 250 biomarkers have been identified so far. The complexity of the sepsis process and the increased sensitivity of various detection techniques will lead to the emergence of new biomarkers. However, there is still a lack of specific diagnostic biomarkers and effective therapeutic approaches for sepsis in clinical practice. Therefore, the search for reliable biomarkers and the evaluation of the role of biomarkers in sepsis will undoubtedly aid in clinical decision-making. This article reviews the advances on research of sepsis biomarkers in order to improve understanding of current biomarkers of sepsis, and provide reference for the application of biomarkers in clinical diagnosis, treatment, and prognosis of sepsis.

脓毒症是危及患者生命的疾病。生物标志物可用于对脓毒症的诊断、治疗和预后评估。近年来不断有新的脓毒症生物标志物被发现，迄今已确定的生物标志物超过250种。脓毒症发生过程的复杂性以及各种检测技术灵敏度的提高将会导致新的生物标志物不断涌现。但针对脓毒症，目前临床上仍缺乏特异性的用于诊断的生物标志物以及有效的治疗方法。因此，寻找可靠的生物标志物以及评估生物标志物在脓毒症中的运用无疑有助于指导临床决策。该文综述了脓毒症生物标志物的研究现状，以期加强对目前脓毒症生物标志物的认识，为生物标志物运用于脓毒症的诊断、治疗和预后评估提供参考。.

PubMed Disclaimer

Conflict of interest statement

利益冲突 所有作者均声明不存在利益冲突

Similar articles

See all similar articles

Cited by

References

    1. Zhang P, Zou B, Liou YC, et al. The pathogenesis and diagnosis of sepsis post burn injury[J/OL]. Burns Trauma, 2021, 9: tkaa047[2023-03-20]. https://pubmed.ncbi.nlm.nih.gov/33654698/. DOI: 10.1093/burnst/tkaa047.

    1. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200–211. doi: 10.1016/S0140-6736(19)32989-7. - DOI - PMC - PubMed
    1. Pierrakos C, Vincent JL. Sepsis biomarkers: a review. Crit Care. 2010;14(1):R15. doi: 10.1186/cc8872. - DOI - PMC - PubMed
    1. Sinha M, Jupe J, Mack H, et al. Emerging technologies for molecular diagnosis of sepsis. Clin Microbiol Rev. 2018;31(2):e00089–17. doi: 10.1128/CMR.00089-17. - DOI - PMC - PubMed
    1. Lippi G. Sepsis biomarkers: past, present and future. Clin Chem Lab Med. 2019;57(9):1281–1283. doi: 10.1515/cclm-2018-1347. - DOI - PubMed

LinkOut - more resources