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Comment
. 2023 Nov;44(11):868-870.
doi: 10.1016/j.it.2023.09.008. Epub 2023 Oct 6.

Dietary fibers affecting gastrointestinal immunity

Laurence Zitvogel  1 , Guido Kroemer  2
Affiliations
Comment

Dietary fibers affecting gastrointestinal immunity

Laurence Zitvogel et al. Trends Immunol. 2023 Nov.

Abstract

Dietary fibers, including chitin, have a major impact on gastrointestinal (GI) physiology and immunity. Two recent articles, by Parrish et al. and Kim et al., credit depletion of dietary fibers or supplementation with chitin, with negative and positive effects, respectively, on the immune system of the murine digestive tract. This has relevant implications for food allergies and systemic metabolism.

Keywords: Akkermansia muciniphila; chitinase; mechanoreceptors; obesity.

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Conflict of interest statement

Declaration of interests L.Z. has held research contracts with Glaxo Smyth Kline, Incyte, Lytix, Kaleido, Innovate Pharma, Daiichi Sankyo, Pilege, Merus, Transgene, 9 m, Tusk, and Roche; was on the on the Board of Directors of Transgene; is a cofounder of everImmune; and holds patents covering the treatment of cancer and the therapeutic manipulation of the microbiota. G.K. has held research contracts with Daiichi Sankyo, Eleor, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Tollys, and Vascage; is on the Board of Directors of the Bristol Myers Squibb Foundation France; is a scientific co-founder of everImmune, Osasuna Therapeutics, Samsara Therapeutics, and Therafast Bio; is on the scientific advisory boards of Hevolution, Institut Servier, and Longevity Vision Funds; is the inventor of patents covering therapeutic targeting of aging, cancer, cystic fibrosis, and metabolic disorders; his brother, Romano Kroemer, was an employee of Sanofi and now consults for Boehringer-Ingelheim. The funders had no role in the design of the study; in the writing of the manuscript, or in the decision to publish the results.

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