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. 2023 Nov;23(6):1043-1050.
doi: 10.1111/psyg.13028. Epub 2023 Oct 8.

Relationship between eating problems and the risk of dementia: A retrospective study

Weiyi Sun  1 , Teruyuki Matsuoka  1   2 , Ayu Imai  1 , Jin Narumoto  1
Affiliations

Relationship between eating problems and the risk of dementia: A retrospective study

Weiyi Sun et al. Psychogeriatrics. 2023 Nov.

Abstract

Background: Older adults and individuals with decreased cognition often experience appetite changes and weight loss. As weight loss can result in cognitive decline, change in appetite may be an important contributor to the onset of dementia. However, there is a lack of relevant studies on this topic. This study aimed to determine the relationship between appetite changes, weight loss, and dementia onset.

Methods: A total of 135 patients with normal cognitive function, subjective cognitive impairment, and mild cognitive impairment who were assessed using the Neuropsychiatric Inventory 12 item version (NPI-12) and followed up for at least 1 month were enrolled in the study. All patients underwent a Mini-Mental State Examination (MMSE). Eating problems were assessed using the NPI Eating Problems Score. Appetite and weight loss were assessed at the first visit by caregivers. Kaplan-Meier survival analyses with a log-rank test were used to compare the time to the onset of dementia between the presence or absence of the NPI eating problems, appetite loss, weight loss, or NPI depression scores. Cox proportional hazards regression models using the forced entry method were employed to estimate the hazard ratio (HR) for dementia.

Results: Weight loss was significantly related to dementia onset (P = 0.027) in the Kaplan-Meier survival analyses, while eating problems, appetite loss, and depression showed no significant association (P = 0.519, P = 0.326, and P = 0.317, respectively). In the Cox proportional hazards regression models, the MMSE score was found to be a significant factor (P = 0.021, HR = 0.871); moreover, weight loss tended to increase the risk of dementia onset (P = 0.057, HR = 1.694).

Conclusions: Weight loss experienced by older adults could contribute to an increased risk of developing dementia.

Keywords: Alzheimer's disease; appetite; dementia; mild cognitive decline; subjective cognitive impairment; weight loss.

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References

    1. Nichols E, Steinmetz JD, Vollset SE et al. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019. Lancet Public Health 2022; 7: e105-e125.
    1. Nakahori N, Sekine M, Yamada M, Tatsuse T, Kido H, Suzuki M. Future projections of the prevalence of dementia in Japan: results from the Toyama dementia survey. BMC Geriatr 2021; 21: 602.
    1. Livingston G, Huntley J, Sommerlad A et al. Dementia prevention, intervention, and care: 2020 report of the lancet commission. Lancet 2020; 396: 413-446.
    1. Byers AL, Yaffe K. Depression and risk of developing dementia. Nat Rev Neurol 2011; 7: 323-331.
    1. Li Y, Aggen S, Shi S et al. Subtypes of major depression: latent class analysis in depressed Han Chinese women. Psychol Med 2014; 44: 3275-3288.