Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct 9;8(1):383.
doi: 10.1038/s41392-023-01617-y.

Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia

Janusz von Renesse  1   2 , Peter Mirtschink  3   4
Affiliations

Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia

Janusz von Renesse et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Elevated levels of Oncostatin M (OSM) observed in tumor-bearing mice and cachectic cancer patients induce an increased expression of the transmembrane receptor for the A2 isoform of Ectodysplasin A (EDA2R), presumably via the JAK/STAT3 pathway. Subsequently stimulation of EDA2R by its ligand EDA-A2 activates the noncanonical NF-κB pathway in a NIK kinase dependent manner inducing the expression of Atrogin1 and the muscle RING-finger protein-1 (MuRF1). This process results in muscle wasting due to accelerated protein degradation. Cartoon created with Biorender.com
See this image and copyright information in PMC

References

    1. Bilgic SN, et al. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. Nature. 2023;617:827–834. doi: 10.1038/s41586-023-06047-y. - DOI - PubMed
    1. Baracos VE, et al. Cancer-associated cachexia. Nat. Rev. Dis. Prim. 2018;4:1–18. - PubMed
    1. Baazim H, Antonio-Herrera L, Bergthaler A. The interplay of immunology and cachexia in infection and cancer. Nat. Rev. Immunol. 2022;22:309–321. doi: 10.1038/s41577-021-00624-w. - DOI - PMC - PubMed
    1. Barbera, M. C. et al. Increased expression of ectodysplasin A2 receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark. Preprint at 10.21203/rs.3.rs-774469/v1 (2021).
    1. Ferrer M, et al. Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. Cell Metab. 2023;35:1147–1162.e7. doi: 10.1016/j.cmet.2023.05.008. - DOI - PMC - PubMed