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. 2023 Dec 1;27(12):712-719.
doi: 10.14744/AnatolJCardiol.2023.3381. Epub 2023 Oct 9.

The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome

İbrahim Etem Çelik  1 , Selçuk Öztürk  2 , Mikail Yarlıoğlu  1 , Ozan Barutçu  1 , Onur Akgün  3 , Mustafa Duran  1 , Şükrü Yorulmaz  4 , Sani Namık Murat  1
Affiliations

The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome

İbrahim Etem Çelik et al. Anatol J Cardiol. .

Abstract

Background: The atherogenic index of plasma (AIP) is a biomarker of plasma atherogenicity. Elevated AIP is linked with adverse cardiac events. We sought to examine the association of admission AIP and no-reflow phenomenon (NRP) in acute coronary syndrome (ACS) patient population treated with percutaneous coronary intervention (PCI).

Methods: Eight hundred eight-four ACS patients were included to statistical tests retrospectively and classified according to the occurrence of NRP: NRP (-) (n = 662) and NRP (+) (n = 186). AIP levels were calculated through the formula log10 (triglyceride-to-high-density lipoprotein cholesterol ratio).

Results: AIP levels were higher in NRP (+) patients compared to NRP (-) group patients. The receiver operating characteristic (ROC) curve analysis for AIP to predict NRP yielded an area under the ROC curve value 0.643 [95% confidence interval (CI): 0.596-0.690, P <.001]. AIP was associated with NRP in univariate logistic regression analysis [Odds Ratio (OR): 2.46; P =.001; CI: 1.44 (lower limit)-4.21 (upper limit)]. However, AIP did not emerge as a significant prognostic factor of NRP in multiple logistic regression analysis [OR: 2.11; P =.422; CI: 0.34 (lower limit)-13.11 (upper limit)]. On the other hand, peak troponin T (log10) was an independent prognostic factor for NRP [OR: 0.13; P <.001; CI: 0.10 (lower limit)-0.37 (upper limit)] occurrence.

Conclusion: The AIP level on admission is not a statistically significant prognostic factor of NRP. However, peak troponin T (log10) is an independent prognostic parameter of NRP.

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Figures

Figure 1.
Figure 1.
Comparison of atherogenic index of plasma levels in patients with reflow and no-reflow phenomenon.
Figure 2.
Figure 2.
Receiver operating characteristic curve analysis of atherogenic index of plasma to predict no-reflow phenomenon.
See this image and copyright information in PMC

References

    1. Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2018;39(2):119 177. ( 10.1093/eurheartj/ehx393) - DOI - PubMed
    1. Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the ­European Society of Cardiology (ESC). Eur Heart J 2016;37(3):267 315. ( 10.1093/eurheartj/ehv320) - DOI - PubMed
    1. Reffelmann T, Hale SL, Li G, Kloner RA. Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2002;282(2):H766 H772. ( 10.1152/ajpheart.00767.2001) - DOI - PubMed
    1. Rezkalla SH, Dharmashankar KC, Abdalrahman IB, Kloner RA. No-reflow phenomenon following percutaneous coronary intervention for acute myocardial infarction: incidence, outcome, and effect of pharmacologic therapy. J Interv Cardiol. 2010;23(5):429 436. ( 10.1111/j.1540-8183.2010.00561.x) - DOI - PubMed
    1. Galasso G, Schiekofer S, D'Anna C, et al. No-reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. A review of the current literature and future perspectives. Angiology. 2014;65(3):180 189. ( 10.1177/0003319712474336) - DOI - PubMed