Study of the elimination kinetics of torasemide, a novel loop diuretic, in renal insufficiency

Abstract

The plasma concentration of torasemide was determined as a function of time in 8 patients with impaired renal function (creatinine clearance less than or equal to 25 ml/min). The elimination half-life (1.3 to 3.8 h), the volume of distribution (0.12 to 0.29 l/kg), and the total body clearance (0.02 to 0.10 l/kg X h) were similar to those observed in normal volunteers.