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. 2023 Sep;57(3):265-272.
doi: 10.15644/asc57/3/7.

Serum Concentration of Vitamin D in Patients with Oral Lichen Planus

Ana Družijanić  1 , Livia Cigić  1   2 , Ana Glavina  3 , Mirna Draganja  2 , Dinko Martinović  4 , Mare Ković  2
Affiliations

Serum Concentration of Vitamin D in Patients with Oral Lichen Planus

Ana Družijanić et al. Acta Stomatol Croat. 2023 Sep.

Abstract

Objectives: The vitamin D receptor is involved in immunologically mediated diseases such as oral lichen planus. Some studies suggest an association between lower vitamin D concentrations and a higher risk of inflammatory conditions such as oral lichen planus. The aim of this study was to investigate 1) whether there is a difference in serum vitamin D concentration in patients with oral lichen planus compared to patients in the control group, 2) whether there is a difference in serum vitamin D concentration in patients with erosive compared to non-erosive forms of oral lichen planus, 3) whether there is a difference in serum vitamin D concentration in patients with developed oral cancer and those without cancer.

Material and methods: The study included 68 patients, 34 with oral lichen planus and 34 healthy controls. Fasting venous blood was taken from each participant to determine serum concentrations of vitamin D.

Results: The T-test results confirmed a statistically significant lower serum vitamin D concentration in patients with oral lichen planus compared to the control group (p=0.001). According to the results, a statistically significant lower serum vitamin D concentration was found in patients with erosive form OLP. All five patients with oral cancer, which was developed from erosive OLP, had low serum vitamin D concentrations.

Conclusions: Determination of serum vitamin D concentration could be important for monitoring OLP patients to prevent the development of severe clinical manifestations of erosive OLP and the conversion of symptomatic lesions to oral cancer.

Keywords: Calcitriol Receptors; MeSH Terms: Serum; Mouth Neoplasms; Oral Cancer; Oral Lichen Planus; Vitamin D; Vitamin D Deficiency.

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Conflict of interest statement

Conflict of interest There are no conflicts to declare.

Figures

Figure 1
Figure 1
Vitamin D serum concentration in patients with non-erosive and erosive forms of OLP.
Figure 2
Figure 2
Pareto diagram of the dependence of the t-values: a) of OLP type on selected predictor variables; b) of the occurrence of oral cancer on selected predictor variables.
See this image and copyright information in PMC

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