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Review
. 2023 Sep 21:13:1242173.
doi: 10.3389/fcimb.2023.1242173. eCollection 2023.

The effect of temperature on dengue virus transmission by Aedes mosquitoes

Zhuanzhuan Liu  1 , Qingxin Zhang  2 , Liya Li  2 , Junjie He  2 , Jinyang Guo  2 , Zichen Wang  2 , Yige Huang  2 , Zimeng Xi  2 , Fei Yuan  1 , Yiji Li  3 , Tingting Li  3
Affiliations
Review

The effect of temperature on dengue virus transmission by Aedes mosquitoes

Zhuanzhuan Liu et al. Front Cell Infect Microbiol. .

Erratum in

Abstract

Dengue is prevalent in tropical and subtropical regions. As an arbovirus disease, it is mainly transmitted by Aedes aegypti and Aedes albopictus. According to the previous studies, temperature is closely related to the survival of Aedes mosquitoes, the proliferation of dengue virus (DENV) and the vector competence of Aedes to transmit DENV. This review describes the correlations between temperature and dengue epidemics, and explores the potential reasons including the distribution and development of Aedes mosquitoes, the structure of DENV, and the vector competence of Aedes mosquitoes. In addition, the immune and metabolic mechanism are discussed on how temperature affects the vector competence of Aedes mosquitoes to transmit DENV.

Keywords: Aedes aegypti; Aedes albopictus; dengue virus; temperature; vector competence.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Effects of temperature on the vector competence of Ae. albopictus. When the temperature exceeds 32°C, the mortality rate of Ae.albopictus increases. When the temperature falls below 18°C, Ae.albopictus does not transmit DENV. At 18°C, DENV is localized to the midgut of Ae.albopictus and proliferate.DENV breaks through the midgut barrier and invades the salivary glands of Ae.albopictus between 23°C and 32°C. At 28°C, the RNAi pathway, Toll pathway, and IMD pathway of the midgut in Ae. albopictus are enhanced.
Figure 2
Figure 2
The temperature affects the midgut’s immunity to change the vector competence of Ae.aegypti. The impairment of RNAi pathways increases DENV titers in midgut at low temperature, making the viruses easily disseminate to other tissues and shorten the EIP. Sucking blood activates GABA associated system, enhancing DENV replication in the midgut of Ae.aegypti by inhibiting the IMD pathway.
Figure 3
Figure 3
The temperature affects the metabolism to change the vector competence of Ae.aegypti. At 20°C, the protein G12 involved in blood meal digestion and nitrile-specific detoxification increases, and the zinc carboxypeptidase involved in blood meal digestion significantly downregulates, which lead to form a PM. The PM slows down the spread of pathogens and reduces vector competence.
See this image and copyright information in PMC

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