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. 1986 Dec;94(3):812-6.
doi: 10.1016/0014-4886(86)90262-1.

DSP-4 treatment accelerates kindling

G Carre, C Harley

DSP-4 treatment accelerates kindling

G Carre et al. Exp Neurol. 1986 Dec.

Abstract

Norepinephrine depletion of the central nervous system by peripheral N-(2-chloroethyl)-N-ethyl bromobenzylamine administration accelerates the development of seizures kindled by repeated stimulation of the amygdala. These data, in conjunction with previous 6-hydroxydopamine data, demonstrate the robustness of this phenomenon and emphasize the importance of noradrenergic innervation originating from the locus ceruleus in the suppression of seizure development.

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