Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug 22;9(9):e19204.
doi: 10.1016/j.heliyon.2023.e19204. eCollection 2023 Sep.

Evaluation of the ovarian reserve in women and adolescent girls with Hashimoto's thyroiditis by serum anti-Müllerian hormone level: A systematic review and meta-analysis

Cui-Juan Shi  1   2 , Tian-Rui Shao  1   2 , Xudong Zhao  1   2 , Bin Wang  1   2
Affiliations

Evaluation of the ovarian reserve in women and adolescent girls with Hashimoto's thyroiditis by serum anti-Müllerian hormone level: A systematic review and meta-analysis

Cui-Juan Shi et al. Heliyon. .

Abstract

Objectives: Several researchers performed case-control studies to explore the relationship between Hashimoto's thyroiditis(HT) and ovarian reserve using anti-Müllerian hormone(AMH) in adolescent girls and women. But the results among these studies are inconsistent and the relationship between HT and ovarian reserve is still controversial. The study aimed to conduct the meta analysis of case-control studies to confirm the relationship between HT and ovarian reserve using AMH.

Methods: 6 electronic databases including PubMed, EMBASE, the Cochrane Library, China National Knowledge Internet(CNKI), SinoMed and Wanfang were searched from inception to December 2021. Endnote X7.0 software was applied to managing all the relevant records. Then data extraction and evaluation of methodological quality of included studies were conducted after two-step selection.Review manager 5.4 version software and Stata 12.0 version software were used to perform all statistical analyses.

Results: 10 case-control studies involving 1202 individuals were included in the present study. The preliminary results revealed AMH values were significantly higher in adolescent girls with euthyroid HT compared with healthy adolescent girls(MD = 1.97; 95%CI, 1.43-2.51; P < 0.001; I2 = 0%). The pooled results in the subgroup of female adults with euthyroid HT showed AMH values were not significantly different between patients with HT and healthy women(MD = -0.21; 95%CI, -0.51-0.09; P = 0.18; I2 = 38%). The pooled results in the two subgroups of female adults with subclinical hypothyroidism and overt hypothyroidism both showed AMH values were significantly lower in the HT group compared with healthy women [(MD = -0.60; 95%CI, -0.86 to -0.34; P < 0.001; I2 = 0%), (MD = -1.34; 95%CI, -1.94 to -0.74; P < 0.001; I2 = 65%)].

Conclusions: Ovarian reserve evaluated by serum AMH concentration is affected by female adults with subclinical hypothyroidism and overt hypothyroidism. The AMH level was significantly higher in euthyroid adolescent girls.

Keywords: Hashimoto's thyroiditis; Meta analysis; Ovarian reserve; anti-Müllerian hormone.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
The flow diagram of searching and selecting of records.
Fig. 2
Fig. 2
Meta analysis of AMH level.
Fig. 3
Fig. 3
Meta analysis of AMH level in subgroup of adolescent girls.
Fig. 4
Fig. 4
Meta analysis of AMH level in subgroup of female adults.
Fig. 5
Fig. 5
The funnel plot of 10 studies.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Weetman A.P. An update on the pathogenesis of Hashimoto's thyroiditis. J. Endocrinol. Invest. 2021;44(5):883–890. doi: 10.1007/s40618-020-01477-1. - DOI - PMC - PubMed
    1. Ralli M., Angeletti D., Fiore M., D'Aguanno V., Lambiase A., Artico M., de Vincentiis M., Greco A. Hashimoto's thyroiditis: an update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmun. Rev. 2020;19(10) doi: 10.1016/j.autrev.2020.102649. - DOI - PubMed
    1. Ragusa F., Fallahi P., Elia G., Gonnella D., Paparo S.R., Giusti C., Churilov L.P., Ferrari S.M., Antonelli A. Hashimotos' thyroiditis: epidemiology, pathogenesis, clinic and therapy. Best Pract Res Clin Endocrinol Metab. 2019;33(6) doi: 10.1016/j.beem.2019.101367. - DOI - PubMed
    1. Ott J., Meusel M., Schultheis A., Promberger R., Pallikunnel S.J., Neuhold N., Hermann M. The incidence of lymphocytic thyroid infiltration and Hashimoto's thyroiditis increased in patients operated for benign goiter over a 31-year period. Virchows Arch. 2011;459(3):277–281. doi: 10.1007/s00428-011-1130-x. - DOI - PubMed
    1. Caturegli P., De Remigis A., Chuang K., Dembele M., Iwama A., Iwama S. Hashimoto's thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology records. Thyroid. 2013;23(2):142–150. doi: 10.1089/thy.2012.0554. - DOI - PMC - PubMed

LinkOut - more resources