Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 18:36:102424.
doi: 10.1016/j.pmedr.2023.102424. eCollection 2023 Dec.

The effects of sedentary behaviour on patients with peripheral arterial Disease: A systematic review

Marwa Said  1 , Baker Ghoneim  1 , Jennifer Jones  1   2 , Wael Tawfick  1   2
Affiliations
Review

The effects of sedentary behaviour on patients with peripheral arterial Disease: A systematic review

Marwa Said et al. Prev Med Rep. .

Abstract

Sedentary behavior has recently emerged as a risk factor for cardiometabolic diseases. The objective of this review was to assess the relationship between sedentary behavior and peripheral arterial disease (PAD). Using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we performed an electronic search across databases including Cochrane Central Register of Controlled Trials, Embase, MEDLINE (Ovid), CINHAL and PubMed to identify studies focusing on sedentary behavior and PAD. A total of 678 records fulfilled eligibility; 166 duplicates were removed, 487 were excluded at the title and abstract level and 15 studies were excluded at the full article level. Thus, our review comprised 10 studies of 20,064 patients with mean age 67.4 years. The average sedentary time was 544.9 min/day. The current review findings indicate that patients with PAD exhibited prolonged periods of sedentary behavior. Furthermore, sedentary behavior among patients with PAD was associated with lower survival rates. The included studies also reported varied outcomes regarding walking distance with some showing an association between reduced sedentary behavior and increased total walking distance. A randomized controlled trial in this review highlighted that reducing sedentary time among patients with PAD improved walking distance. Therefore, the connection between sedentary behavior and PAD seems to be bidirectional. Sedentary time could contribute to PAD development, and PAD-related symptoms may lead to prolonged sedentary behavior. A call for research investigating the link between PAD and sedentary time. Additionally, intervention studies are needed to target the reduction of sedentary time in patients with PAD.

Keywords: Intermittent claudication; Peripheral arterial disease; Sedentary behavior; Sedentary time; Sitting time.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We sincerely thank the University of Galway for covering the publication fees, which enabled us to share this work more widely

Figures

Fig. 1
Fig. 1
PRISMA flowchart of the selection process. A PRISMA flowchart illustrates a total of 512 title and abstract records were screened, out of which 487 records were excluded. Twenty-five studies were assessed for full-text eligibility. A total of 15 reports were excluded, resulting in 10 studies being included in the current systematic review.
Fig. 2
Fig. 2
The mean sedentary time (min/day) among studies using accelerometer for sedentary time assessment. A bar chart illustrates the various types of accelerometers utilized in the studies that were included in the current review to objectively measure sedentary time in relation to high-risk sitting (480 min/day), with the high-risk sitting being represented by the colour black.
See this image and copyright information in PMC

References

    1. Amidou SA, Houehanou YC, Houinato SD, Aboyans V, Sonou A, Saka D, Houinato M, Desormais I, Magne J, Houenassi MD, Preux PM, Lacroix P; TAHES Group. Epidemiology of lower extremity artery disease in a rural setting in Benin, West Africa: The TAHES study. Int J Cardiol. 2018 Sep 15;267:198-201. doi: 10.1016/j.ijcard.2018.05.099. Epub 2018 May 26. Erratum in: Int J Cardiol. 2018 Nov 15;271:406. PMID: 29859709. - PubMed
    1. Amoh-Tonto C.A., Malik A.R., Kondragunta V., Ali Z., Kullo I.J. Brachial-ankle pulse wave velocity is associated with walking distance in patients referred for peripheral arterial disease evaluation. Atherosclerosis. 2009;206(1):173–178. doi: 10.1016/j.atherosclerosis.2009.02.003. - DOI - PMC - PubMed
    1. Andersen P., Kragholm K., Torp-Pedersen C., Jensen S.E., Attar R. The impact of peripheral artery disease on major adverse cardiovascular events following myocardial infarction. International journal of cardiology. 2021;343:131–137. doi: 10.1016/j.ijcard.2021.08.053. - DOI - PubMed
    1. Atkin A.J., Gorely T., Clemes S.A., Yates T., Edwardson C., Brage S., Salmon J., Marshall S.J., Biddle S.J. Methods of measurement in epidemiology: sedentary behavior. International journal of epidemiology. 2012;41(5):1460–1471. doi: 10.1093/ije/dys118. - DOI - PMC - PubMed
    1. Aunger J., Wagnild J. Objective and subjective measurement of sedentary behavior in human adults: A toolkit. American journal of human biology : the official journal of the Human Biology Council. 2022;34(1):e23546. - PMC - PubMed

LinkOut - more resources