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Comment
. 2024 Jul 11;73(8):1403-1404.
doi: 10.1136/gutjnl-2023-330364.

Mendelian randomisation shows diverticular disease and irritable bowel syndrome increase the risk of haemorrhoidal disease

Simonas Juzenas  1   2 , David Ellinghaus  2 , Serena Sanna  3   4 , Andre Franke  2   5 , Mauro D'Amato  6   7   8
Affiliations
Comment

Mendelian randomisation shows diverticular disease and irritable bowel syndrome increase the risk of haemorrhoidal disease

Simonas Juzenas et al. Gut. .
No abstract available

Keywords: DIVERTICULAR DISEASE; GENETICS; IRRITABLE BOWEL SYNDROME.

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Conflict of interest statement

Competing interests: MD has received unrestricted research grants and consulting fees from QOL Medical LLC.

Figures

Figure 1
Figure 1
Bi-directional Mendelian randomisation (MR) analyses indicate a causal relationship between the effects of SNPs associated with DIV and IBS, respectively, on the development of HEM. The graph illustrates the associations between (A) IBS and HEM as well as (B) DIV and HEM, with ORs and their corresponding 95% CIs shown on the x-axis. The y-axis represents HEM as either an exposure or an outcome variable. MR analyses were conducted by using inverse variance weighted (IVW), MR Egger, weighted median, simple mode, weighted mode and CAUSE methods. Significance levels: *p<0.05; **p<0.01; ***p<0.001; else not significant. DIV, diverticular disease; HEM, haemorrhoidal disease.
See this image and copyright information in PMC

Comment on

References

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